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Weight loss jabs: What happens when you stop taking them

submitted by neom+(OP) on 2025-12-21 19:58:11 | 51 points 121 comments
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replies(14): >>belter+f4 >>Option+65 >>jmward+95 >>Asooka+e5 >>Taikon+H5 >>asciim+h7 >>jeffbe+d8 >>koziko+59 >>iwantt+7a >>Sol-+Ea >>spacem+Xb >>maxaw+le >>lr4444+Ah >>daft_p+LT
1. belter+f4[view] [source] 2025-12-21 20:29:52
>>neom+(OP)
TLDR: "...evidence so far suggests that, between one and three years after stopping the medication, people will see a "significant proportion of weight" go back on...Somewhere in the region of 60 to 80% of the weight that you lost will return..."
replies(3): >>stinos+A4 >>isopro+36 >>BoingB+Q8
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2. stinos+A4[view] [source] [discussion] 2025-12-21 20:32:39
>>belter+f4
What's striking here is that this is roughly the same outcome as essentially every other diet (with the intent of losing weight) out there. It's just more expensive. And possibly more hyped.
replies(3): >>mgracz+O4 >>gerald+45 >>blindr+i5
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3. mgracz+O4[view] [source] [discussion] 2025-12-21 20:33:50
>>stinos+A4
And it works much better for most people
replies(2): >>nostre+75 >>tartor+xc
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4. gerald+45[view] [source] [discussion] 2025-12-21 20:35:49
>>stinos+A4
Diet is the food you eat. If you change the food you eat, you’ve changed your diet.

Any attempt at a temporary food change is already a failure for long term health.

5. Option+65[view] [source] 2025-12-21 20:35:59
>>neom+(OP)
Being overweight is a chronic disease.

Just like alcoholism, or any kind of other addictions.

I've struggled with alcohol abuse, and once you come to the realization that you're abusing it, the fix FOR ME was relatively simple: I stopped (under medical supervision) drinking, or to be more precise: I stopped starting to drink. I have no problems not drinking, I have a problem that when I start I cannot stop.

I have the same issue with food. Not eating is a lot easier than stopping to eat. But I cannot completely stop eating.

Yet with alcohol people are like: hey, good for you.

With my weight issues people are like: dude, just eat less, or exercise more.

(I stopped sharing the food story with people).

replies(5): >>true2o+y5 >>jchw+68 >>metalm+n9 >>paulpa+Ka >>throw9+9c
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6. nostre+75[view] [source] [discussion] 2025-12-21 20:36:08
>>mgracz+O4
Yeah I think this is the missing piece. Same impact as dieting but with higher adherence and duration is a huge win.
7. jmward+95[view] [source] 2025-12-21 20:36:46
>>neom+(OP)
Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medications out there. A constant issue here is that we keep calling this a 'weight loss drug' and society views being fat as a moral failing ant that you 'just don't have the will power' to overcome. We need to stop. If this is a lifelong drug it is worth it compared to the relatively ineffective, and just as lifelong, alternatives out there.
replies(6): >>3roden+X6 >>AaronA+B9 >>paulpa+Dc >>pupppe+Ow >>nradov+zD >>xorcis+QC1
8. Asooka+e5[view] [source] 2025-12-21 20:37:02
>>neom+(OP)
Can't be worse long-term than inhaling nicotine, the previous widely deployed strategy to combat food cravings.
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9. blindr+i5[view] [source] [discussion] 2025-12-21 20:37:23
>>stinos+A4
It's not hyped. It's the most effective way I've seen the people around me lose weight. Some of them have lost a tremendous amount of weight very quickly.

But a know a couple of them that went off it and the weight came back pretty quickly. It really is just a suppression of hunger, nothing more than that.

replies(2): >>sixtyj+s8 >>hamand+J8
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10. true2o+y5[view] [source] [discussion] 2025-12-21 20:39:03
>>Option+65
What works for me is to eat highly nutritious low-glycemic food until I feel full (eggs, avocado, quinoa, etc)

Otherwise I over eat crap and gain weight easily

replies(2): >>skrebb+y7 >>paulpa+yd
11. Taikon+H5[view] [source] 2025-12-21 20:39:43
>>neom+(OP)
Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0]

The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consumed. Revita basically re-surfaces the duodenum.

So, the idea is that you get to a lower weight with the GLP-1 drugs, and then Revita can hopefully reset your set point there.

Their first clinical trial is still in progress, but I think it's interesting to watch.

[0]: https://www.fractyl.com/our-platforms/revita/

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12. isopro+36[view] [source] [discussion] 2025-12-21 20:41:18
>>belter+f4
Taking recovered drug addicts and placing them in a situation where everyone's using all the time would probably lead to equally bad outcomes.

Our food is too rich in calories, too abundantly available, and too addictive for most people.

replies(1): >>uxjw+qi2
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13. 3roden+X6[view] [source] [discussion] 2025-12-21 20:49:27
>>jmward+95
I don’t think that’s a fair assessment. I’m all for life-long drugs that help with weight loss, I don’t view it as a moral failing. That said, it is easy to see why so many people are concerned about these drugs: people taking them can look terrible (“ozempic face”). Gaunt, sick, hollowed out, look at people like Sharon Osbourne, that’s the public face of these drugs. And so when people are committing to life-long use of these drugs, it is being viewed with the very visible side effects in mind, and that is concerning to a lot of people after these drugs seemingly appeared overnight.
replies(1): >>hamand+Y7
14. asciim+h7[view] [source] 2025-12-21 20:51:42
>>neom+(OP)
> "The environment that people live in needs to be one that promotes health, not weight gain. […] Obesity is not a GLP-1 deficiency," he says.

This is my biggest issue with weight healthcare, the idea that if only the patient would eat correctly they wouldn’t be overweight. It’s not some moral failing a person often over eats, it very well could be some physiological issue that should be treated. It would be like telling someone with asthma that they just need to get into better shape to breathe better.

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15. harvey+q7[view] [source] [discussion] 2025-12-21 20:52:29
>>Taikon+H5
Surprised this is still in first trial. I can recall reading about something like it in 2017. Apparently clearing the duodenal mucosa is a preparatory step for a gastric band fitting, but they found patients were making improvements before the bands were being fitted so a study was started to see if this less invasive procedure might be enough by itself.
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16. skrebb+y7[view] [source] [discussion] 2025-12-21 20:53:06
>>true2o+y5
How many years have you been able to keep that diet up?
replies(1): >>true2o+sy
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17. hamand+Y7[view] [source] [discussion] 2025-12-21 20:56:42
>>3roden+X6
"Ozempic face" is actually just "unhealthy rapid weight loss face". Ozempic makes it easier to starve yourself, but that isn't how it's supposed to be used.
replies(3): >>yellow+ma >>manmal+pb >>tartor+Wb
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18. jchw+68[view] [source] [discussion] 2025-12-21 20:57:31
>>Option+65
It's frustrating.

"Just Eat Less" is roughly the way to lose weight, but the problem is not that fat people are so unbelievably stupid that they didn't know this. I am sure for some people it really is that simple. Not us.

My weight has been a bit of a rollercoaster. I've never been terribly thin, but I've been "not technically obese" from time to time. I'm currently back on the downswing, but God, what a pain in the ass. It feels like gaining weight is incredibly easy and losing it is incredibly hard (and I do believe this is validated by the science, because you wind up with more fat cells when you first gain weight, which I guess is both relieving and terrifying.)

No matter how many attempts it takes to fix my body, I'm obviously going to just keep trying, because obesity is horrible for you in so many ways. It saps your energy, it's carcinogenic, it increases your blood pressure and risk of heart disease, but it feels like one of those struggles that is never-ending. I've improved my diet numerous times but it never feels like it's quite enough.

replies(6): >>jeffbe+C8 >>paulpa+Za >>filole+2b >>TheOth+7b >>george+ak >>pton_x+2u
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19. kiba+c8[view] [source] [discussion] 2025-12-21 20:57:55
>>asciim+h7
Until we are able to fix the environment and culture, we're stuck with medications like this. The good news is that glp1 medicine can be used to break addictive behaviors, so it is the very tool that can help change our environment by reducing demand for junk food.

We still need to talk to our Congress critters.

20. jeffbe+d8[view] [source] 2025-12-21 20:58:04
>>neom+(OP)
I guess it's a dialect thing, but I have become accustomed to disregarding absolutely every article that employs the word "jab".
replies(3): >>foglem+o9 >>eterm+r9 >>XorNot+Fc
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21. XorNot+o8[view] [source] [discussion] 2025-12-21 20:59:04
>>asciim+h7
That's what GLP-1 drugs are doing? Like...this is the premier argument as to why they work.
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22. sixtyj+s8[view] [source] [discussion] 2025-12-21 20:59:49
>>blindr+i5
It can be hyped because jabs bring immediate results. And it can be prescribed by almost every doctor so number of people who can report is big, and therefore visible results can be further disseminated (hyped).

But… treatment is working.

Question is at what cost.

If something is too good to be true, one has to ask what is behind it. But perhaps it is a similar situation to when antibiotics were invented.

replies(2): >>XorNot+6d >>array_+sI2
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23. jeffbe+C8[view] [source] [discussion] 2025-12-21 21:00:35
>>jchw+68
> the problem is not that fat people are so unbelievably stupid that they didn't know this

I don't suggest this applies to you, but even a small amount of searching around and reading stuff on the web will reveal a substantial subgroup of outright thermodynamics deniers.

replies(2): >>wwwest+4b >>randal+mb
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24. diziet+E8[view] [source] [discussion] 2025-12-21 21:00:44
>>asciim+h7
I don't have a horse in this race, but from my personal experience eating satiating whole foods with lower glycemic index, higher fiber and protein content makes it very difficult to gain excessive weight.

On the asthma front, from experiences with someone close to me -- getting in great physical shape (with caveats regarding training) DID indeed help greatly with broncho-constriction and higher scores on FEV. Basically symptoms and inhaler use went down tremendously over a few years and a physical transformation.

replies(2): >>randal+Mc >>milch+JB
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25. hamand+J8[view] [source] [discussion] 2025-12-21 21:01:11
>>blindr+i5
> It really is just a suppression of hunger, nothing more than that.

It is actually a lot more than that. Many people on Ozempic report better impulse control (food or otherwise). Many stop or significantly reduce alcohol intake. It seems that gut hormones are linked to reward pathways in the brain.

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26. BoingB+Q8[view] [source] [discussion] 2025-12-21 21:02:03
>>belter+f4
Surprise surprise, it's not like the drug did anything to improve the patient's discipline...
27. koziko+59[view] [source] 2025-12-21 21:04:12
>>neom+(OP)
I did lose 30-40kg about 2 years ago on Ozempic.

I don't count calories. I went off Ozempic (now Mounjaro) and I gain weight at about 0.5-1kg a month.

As I am resistance (gym) training, significant % of that ends up being muscle mass rather than fat.

So I end up taking Mounjaro for about 1-2 months every 3-4 months, approximately 33% of the time being "on".

Funnily, I end up with bulk/cut periods without doing them explicitly. This ends up working well for growing muscles.

Notice all people in the story are women. I guess pairing GLP-likes with bodybuilding works quite well for men. As times goes on, I end up needing mounjaro less due to my increased muscle mass.

replies(2): >>cryzin+ac >>paulpa+Wd
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28. hamand+l9[view] [source] [discussion] 2025-12-21 21:05:18
>>Taikon+H5
> Revita basically re-surfaces the duodenum.

Does this reduce mucous production going forward? Otherwise, it seems like it would be a temporary effect.

replies(1): >>Taikon+Kb
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29. metalm+n9[view] [source] [discussion] 2025-12-21 21:05:18
>>Option+65
since I also share the ability to cold turkey on most anything, what you can completly stop eating is processed food, or anything that requires an advanced chemical engineering degree to decipher, ditch most of the carbs, ALL of the sugar. Meat, veggies,fruit,grains,nuts,the most complex packaged foods I buy are yogurt, and bread from an outfit that contracts farmers to grow wheat, pickles, stuff from wierd and wonderfull ethnic groceries where they openly miss there country and insist on having you try the good stuff!, wild food, tucked away farm markets, but most of all, I put my body in charge, which requires listening, but once you realy clean up, perhaps you will find as I have, that certain off the record indulgences have very significant negative phisiological repercusions, on a one to one basis. but this practice is not for dilly dalyiers, so
replies(1): >>Throwa+ga
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30. foglem+o9[view] [source] [discussion] 2025-12-21 21:05:21
>>jeffbe+d8
That's just what they call it in British English, and this is a BBC article.
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31. eterm+r9[view] [source] [discussion] 2025-12-21 21:05:28
>>jeffbe+d8
> (British) A medical hypodermic injection (vaccination or inoculation).

From https://en.wiktionary.org/wiki/jab

I hope that helps

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32. AaronA+B9[view] [source] [discussion] 2025-12-21 21:06:16
>>jmward+95
But it is factually true that it’s a matter of willpower, no amount of reframing it is going to change that.

It’s not like others like myself, currently on a cut cycle, don’t experience hunger. The idea that we are just “lucky” ignores all the willpower and discipline we fight through to do it ourselves.

I’ve eaten about 800 calories today and it is 4pm. Just finished 90 minutes on the indoor bike. My stomach feels hungry. I experience that and just sit with it. That is the difference.

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33. iwantt+7a[view] [source] 2025-12-21 21:08:25
>>neom+(OP)
We need to start looking at obesity as a hunger disorder, and not as the result of an addiction, a lack of knowledge about nutrition, or a lack of self control.

When an obese person regulates their eating and loses weight, the hunger often doesn't go away - and often increases. This is physical, not psychological hunger. When the obese person almost inevitably returns to eating to fullness, they regain weight.

When a person takes GLP-1s, hunger is greatly reduced, and an obese person can eat less food while still achieving satiety without gaining weight. When they stop taking the GLP-1s, the hunger returns, and when they return to eating to fullness, they regain weight.

Similarly, when a person takes stimulant weight loss medication, they can eat less food while experiencing less hunger, and thus lose weight. Similarly, when they go off of the stimulant (or develop a tolerance), the hunger returns and when they return to eating to fullness, they regain weight.

In many obese people, the hunger is present even when they eat a nutritious meal at the appropriate number of calories to maintain their weight. Common advice is to say "this mix of macros or foods makes me satisfied!" and, well, that's great for you but not universal.

People who naturally feel reasonably satisfied with an appropriate number of calories to maintain their weight still experience hunger, but not with the intensity or insatiability of that hunger that many obese people do.

While it does occur with some who have severe eating disorders, most obese people do not overeat themselves into obesity by continuing to eat long after they're full. They eat until the hunger goes away.

It's the hunger. Take away the hunger, and the weight goes down. Bring back the hunger and the weight goes up. It's simple, it's obvious, and few say it.

replies(1): >>paulpa+Ue
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34. Throwa+ga[view] [source] [discussion] 2025-12-21 21:08:55
>>metalm+n9
I really, really, really like mayonnaise though
replies(1): >>metalm+Jn4
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35. yellow+ma[view] [source] [discussion] 2025-12-21 21:09:25
>>hamand+Y7
Many of the fly by night digital proscribes just jack the dosage to show rapid gains. Coupled with people lying on BMI to get a script is a bad combination and why it’s so obvious.
36. Sol-+Ea[view] [source] 2025-12-21 21:11:07
>>neom+(OP)
Then just continue to take them? The article just once seems to mention side effects and these were suspected to be related to rapid weight loss and less to the drug itself.

Pointless human interest story with some rent-a-quote expert sprinkled in that tries to imply some ominous danger but can't come up with any hard data on that themselves.

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37. paulpa+Ka[view] [source] [discussion] 2025-12-21 21:11:45
>>Option+65
I have observed that being addicted drugs gets way more sympathy than being addicted to food even though the neural pathways and other factors are the same.
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38. paulpa+Za[view] [source] [discussion] 2025-12-21 21:13:42
>>jchw+68
(and I do believe this is validated by the science, because you wind up with more fat cells when you first gain weight, which I guess is both relieving and terrifying.)

the data is pretty clear . the vast majority of dieters fail, even when the bar for success is set really low, like a 2-5% long-term weight loss of starting body weight for an obese person is considered a success.

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39. filole+2b[view] [source] [discussion] 2025-12-21 21:13:50
>>jchw+68
> It feels like gaining weight is incredibly easy and losing it is incredibly hard

I feel like there is more to it.

Obviously, I sympathize with you, and I noticed that when I switch from a bulking cycle to a cutting cycle, it is a bit difficult to adjust for the first couple of weeks as well.

But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even with the help of stuff like weed. And when I don’t work out aggresively and don’t keep track of my cycle, it feels just natural for me to default to eating way less, as opposed to the other way around.

To be clear, this isn’t meant to be a dig at your take. All I mean is that, I feel like the whole issue is a bit more complex.

replies(1): >>paulpa+7c
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40. wwwest+4b[view] [source] [discussion] 2025-12-21 21:13:58
>>jeffbe+C8
Can you provide an example of someone who outright denies thermodynamics?

I’m familiar with people who believe that there are details of how a body metabolizes fuel , expends energy, and generally operates that escape analysis focused on fuel volume and physical activity. I am familiar with people who characterize this as denial of the laws of thermodynamics, but I am not familiar with anyone who seems to believe that there are situations in which the laws of thermodynamics are outright suspended.

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41. TheOth+7b[view] [source] [discussion] 2025-12-21 21:14:24
>>jchw+68
There's a lot of very visible and conscious messaging about losing weight.

There's an equal and opposite level of messaging to keep eating, which is less conscious and runs under the radar.

Snacks are literally designed to be addictive. TV ads start from birth. Most restaurants have huge portion sizes. "Family" and "Festival" events assume overeating is expected. Junk food is cheap and quality food is expensive. Overeating is framed as being "naughty" but also indulgent and nurturing.

All of this is a huge social problem that's not acknowledged at all.

It's very, very hard to Just Eat Less when there's a constant barrage of messaging encouraging you to do the opposite, and you're not even aware of it.

The contradictory messaging is actually a classic crazy-making psychological double bind. So of course it's very difficult to make a dent in this, and even harder to permanently change habits so all the contradictions no longer influence you.

replies(1): >>paulpa+Fb
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42. randal+mb[view] [source] [discussion] 2025-12-21 21:16:04
>>jeffbe+C8
> outright thermodynamics deniers

I've heard people say this before, but when reading those arguments it mostly turns out to be people who think there's something more complicated going on with digestion, excretion, or metabolism such that eaten calories are more efficiently used for some, and burned off or passed through without full processing to some degree for people who self-reportedly "can't gain weight".

replies(1): >>paulpa+id
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43. afavou+ob[view] [source] [discussion] 2025-12-21 21:16:13
>>AaronA+B9
How can you say that with any certainty, though? How do you know that hunger hits you in the exact same way it does another person? That overcoming it requires the exact same amount of willpower in all people?
replies(1): >>AaronA+8c
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44. manmal+pb[view] [source] [discussion] 2025-12-21 21:16:22
>>hamand+Y7
It’s also accelerated muscle loss, even heart tissue. I‘m not saying it’s not worth it, but this should be kept on the radar for sure.
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45. paulpa+Fb[view] [source] [discussion] 2025-12-21 21:17:33
>>TheOth+7b
Most restaurants have huge portion sizes.

ppl keep blaming this, but this is contradicted by shrinkflation, yet people still are getting fatter than ever. There is nothing to stop someone from buying more food to offset smaller portions.

replies(1): >>toyg+Ce
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46. Taikon+Kb[view] [source] [discussion] 2025-12-21 21:17:44
>>hamand+l9
My impression (and I'm not a scientist) is that the mucosal overgrowth comes from eating an obesogenic diet. (Some combination of too much sugar / salt / wrong types of fat?)

If you get the procedure and don't go back to an obesogenic diet, then it should be permanent.

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47. tartor+Wb[view] [source] [discussion] 2025-12-21 21:18:55
>>hamand+Y7
Taking Ozempic also drops a lot of muscular mass and that ozempic face look totally makes sense.

There's no free lunch or wonder drug. While it's effective at weight loss it has a lot of unwanted side effects. And when stopping the drug the weight gain comes back so not sure if it's worth it.

replies(1): >>array_+eD2
48. spacem+Xb[view] [source] 2025-12-21 21:18:59
>>neom+(OP)
If you’re substantially overweight, you have to wonder if the long term side effects of GLP-1 are better than being obese

That said, its a little disheartening to see people who are 10-15kg overweight also resort to these drugs - this kind of excess weight can be fought with simply diet and exercise

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49. manmal+3c[view] [source] [discussion] 2025-12-21 21:19:23
>>AaronA+B9
Congrats, your metabolism (FAO, gluconeogenesis, insulin sensitivity, …) works well. Don’t assume that’s the case for everyone, because it’s well researched that this is highly individual.
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50. paulpa+7c[view] [source] [discussion] 2025-12-21 21:19:51
>>filole+2b
But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even with the help of stuff like weed

You could just have good genetics in which your body is resistant to weight gain or you have a low appetite to begin with. As shown by the worldwide obesity epidemic, this is apparently quite an uncommon problem. 75% of country overweight or obese.

replies(2): >>toyg+df >>pandam+3G
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51. AaronA+8c[view] [source] [discussion] 2025-12-21 21:19:54
>>afavou+ob
My hunger feels 8 trillion times worse than an obese person’s. Since I am making the claim, everyone else has to affirm it now.
replies(1): >>afavou+0f
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52. throw9+9c[view] [source] [discussion] 2025-12-21 21:19:55
>>Option+65
Other countries do not have obese people, but have many drinkers!

It is issue of food and ingrediences. Too many sugars, fructose syrups from corn... If fat american moves to asian country, he loses fat, without changing a diet.

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53. cryzin+ac[view] [source] [discussion] 2025-12-21 21:20:02
>>koziko+59
When you restart taking it after an "off" period, do you immediately resume whatever dose you were at before? Or do you taper up each time? (Curious because I know for many people, side effects level out after they've been at a given dose for long enough, but temporarily return whenever they increase their dose; not sure how "off" periods affect that kind of tolerance.)
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54. AaronA+lc[view] [source] [discussion] 2025-12-21 21:21:08
>>manmal+3c
You know nothing about my metabolism.
replies(1): >>manmal+Jc
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55. tartor+xc[view] [source] [discussion] 2025-12-21 21:22:28
>>mgracz+O4
> And it works much better for most people

I thing it takes less effort to be effective but it has pretty bad side effects.

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56. paulpa+Dc[view] [source] [discussion] 2025-12-21 21:22:45
>>jmward+95
A constant issue here is that we keep calling this a 'weight loss drug' and society views being fat as a moral failing ant that you 'just don't have the will power' to overcome. We need to stop. If this is a lifelong drug it is worth it compared to the relatively ineffective, and just as lifelong, alternatives out there.

I have noticed much less moralizing over the issue now compared to 2-3 years ago. I think more people realize these drug are safe and effective and not 'taking the easy way out', but rather a treatment for a medical problem than just blaming laziness or gluttony.

replies(1): >>thefz+hd
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57. XorNot+Fc[view] [source] [discussion] 2025-12-21 21:22:48
>>jeffbe+d8
The word itself is just insufferable at this point. The media collectively went bonkers for it while describing COVID vaccine delivery.
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58. manmal+Jc[view] [source] [discussion] 2025-12-21 21:23:09
>>AaronA+lc
Well one of those has to work well or you would have fainted by now.
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59. randal+Mc[view] [source] [discussion] 2025-12-21 21:23:27
>>diziet+E8
Before GLP-1s, there was rarely any such thing as "satiation" for me. Getting full was something that happened without the feeling of having had enough. The main effect of wegovy, for me, was having a feeling of not needing to eat rather than just feeling too full to eat. It was quite an experience, and one I am not sure I had had in more than 30 years.
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60. paulpa+Oc[view] [source] [discussion] 2025-12-21 21:23:55
>>manmal+3c
The ability to tolerate discomfort is probably as genetic/inante as metabolism.
replies(2): >>nradov+OD >>xorcis+XA1
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61. XorNot+6d[view] [source] [discussion] 2025-12-21 21:25:57
>>sixtyj+s8
Most developed medical technology doesn't have "a cost". That's puritan morality theater masquerading as wisdom.
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62. thefz+hd[view] [source] [discussion] 2025-12-21 21:26:31
>>paulpa+Dc
The article explains they they are not safe nor effective
replies(1): >>sergio+R91
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63. paulpa+id[view] [source] [discussion] 2025-12-21 21:26:35
>>randal+mb
Right, the body can choose to either convert surplus calories to fat or waste heat. The latter could explain how some individuals are much more resistant to weight gain than others. This is also supported by overfeeding studies, in which controlling for relevant factors, some people gain much more fat on a deliberate calorie surplus than others.
replies(1): >>array_+RG2
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64. paulpa+yd[view] [source] [discussion] 2025-12-21 21:28:35
>>true2o+y5
the problem is, obese or formerly obese people clan eat a lot of anything before the full feeling sets in, no matter what. Eggs, chicken..does not matter.
replies(1): >>true2o+az
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65. XorNot+Qd[view] [source] [discussion] 2025-12-21 21:30:32
>>AaronA+B9
On the one hand I'm impressed but 800 is really super low. I was losing about a kilo a week at the peak of my diet eating double that.
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66. paulpa+Wd[view] [source] [discussion] 2025-12-21 21:30:57
>>koziko+59
I don't count calories. I went off Ozempic (now Mounjaro) and I gain weight at about 0.5-1kg a month.

yeah that is how ppl become obese. over 2-5 years it adds up

Notice all people in the story are women.

Probably due to social media. Women may be more inclined to show off their success online. Also, women respond better to these drugs compared to men.

67. maxaw+le[view] [source] 2025-12-21 21:33:20
>>neom+(OP)
I definitely lost weight easily on wegovy and just as easily gained it back when I stopped taking it. The whole experience definitely drove home how I needed to improve my mental health alongside any “purely physical” intervention. Same situation when I lost weight by meticulously calorie counting.

I think obesity is hard to fix even when you are not a “thermodynamics denier” (as another commenter said) because all you can practice is moderation from the get go. How many people would fail to fix their alcoholism if complete abstinence, even just a period of complete abstinence to rewire the brain, was never an option? They actually had to go down to the pub and practice stopping everyday at 1 pint?

replies(1): >>neom+ch
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68. toyg+Ce[view] [source] [discussion] 2025-12-21 21:35:27
>>paulpa+Fb
Shrinkflation is typically a retail issue, where pricing per unit is a massive psychological factor and competition is fierce and immediate (literally the next shelf). For restaurants it's much easier to just raise prices, or to bulk up plates with cheap stuff like bread.
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69. paulpa+Ue[view] [source] [discussion] 2025-12-21 21:37:36
>>iwantt+7a
In many obese people, the hunger is present even when they eat a nutritious meal at the appropriate number of calories to maintain their weight. Common advice is to say "this mix of macros or foods makes me satisfied!" and, well, that's great for you but not universal.

Yup..the high failure rate of dieting is true regardless of the type of food or the macros. Lecturing to 'just eat healthy' as the default mode of advice does not work for the large majority of obese people..this is supported by the literature and anecdotal evidence.

replies(1): >>shadow+O92
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70. afavou+0f[view] [source] [discussion] 2025-12-21 21:38:07
>>AaronA+8c
But you’re disproving your own point. Other people’s experiences aren’t knowable so you can’t say it’s just a willpower issue.
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71. toyg+df[view] [source] [discussion] 2025-12-21 21:39:27
>>paulpa+7c
> good genetics

This moral judgement whereby losing weight is "good" in absolute, is such bullshit. For most of history, humans have fought starvation literally every day, and often had to make do with minimal caloric intake for weeks or months - in that context, genetics that kept you thin were definitely very bad.

replies(1): >>paulpa+Ag
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72. refibr+ff[view] [source] [discussion] 2025-12-21 21:39:31
>>Taikon+H5
Fascinatingly, the body already has a mechanism for this: fasting. One of the many beneficial side effects is rapid mucosal atrophy, decreasing villus height and crypt depth.

You can find evidence of this in the literature, but it’s absurdly understudied, because big pharma would rather sell you a subscription to life.

Fortunately there are many good people in the world, especially in the field of medicine, who want to help their patients unconditionally. So there are glimmers of hope, like some of the top cardiologists in the world going against status quo and treating patients with fasting regimes instead of surgery.

replies(1): >>yread+Cg
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73. 3roden+wf[view] [source] [discussion] 2025-12-21 21:41:13
>>AaronA+B9
People are different. Using your own achievements as evidence of other’s failings isn’t useful, we are all different. I can fast for 23 hours a day, 365 days a year (omad) with ease, not because I have more willpower than my fat friends, but because I’m different. My fat friends are objectively stronger and more resilient than me in almost every aspect of life, yet by your measure, because hunger doesn’t bother me, I have more willpower than them? Willpower isn’t measured on outcomes.
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74. paulpa+Ag[view] [source] [discussion] 2025-12-21 21:49:20
>>toyg+df
Having a smaller appetite could have been advantageous by allowing food to last longer
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75. yread+Cg[view] [source] [discussion] 2025-12-21 21:49:33
>>refibr+ff
Do you have some good links for that? I only found this

https://www.mdpi.com/2072-6643/16/1/128

which says that the changes reverted quickly after resuming normal feeding

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76. toomuc+Qg[view] [source] [discussion] 2025-12-21 21:50:38
>>Taikon+H5
https://en.wikipedia.org/wiki/Duodenum

Fascinating.

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77. neom+ch[view] [source] [discussion] 2025-12-21 21:53:25
>>maxaw+le
Excuse the ramble: it maybe sucks more for people with eating addictions than alcohol in some sense. I am an alcoholic and I've been sober for, I dunno, years and years now. I did actually go to pubs and cocktail bars when I first got sober, I didn't drink I just sat and felt awful and wanted to drink badly. I felt I needed to learn how the feeling of the craving was going to work so I can plan for it etc, especially when stress creeps in. So, as another comment said, I got sober by stopping the first drink. For me it's very logical, if I have a drink, I will drink, I will not stop, I cannot stop, so if I take the first drink it doesn't matter that is is, it's done, so I don't drink the first drink since I decided that, hence sober.

...I suppose it's hard for someone who struggles with eating to stop food all together. That said, after I got off booze, I started on sugar, never been into sugar in my life, didn't like cake, ice cream any of that stuff, but getting off booze that started, I craved ice cream and stuff all the time, and gave in not realizing what was happening, once I told my dr and he explained the body was substituting the alcohol... so I stopped sweet stuff (mostly all of it, honey and fruit juice seem fine, I don't crave them). I don't have very many cravings any more, I know that "you're going to crave this if you have it more than a few times" feeling as soon as I consume something now, and, I just, don't. Is it hard? Every time, but I prefer the control more tbh.

Maybe I live a kinda boring life now, oh well, at least I feel great.

78. lr4444+Ah[view] [source] 2025-12-21 21:55:46
>>neom+(OP)
Question for people who have trouble losing fat (this was never my problem): have you ever tried instead of dieting to just force yourself to eat more fruits, vegetables, and protein daily while also allowing yourself free range in the remaining appetite room to have whatever? The human mind/brain/whatever doesn't do well with deprivation of a high dopamine reward, but what would happen if you started to shift your tastes by insisting that it get used to a more healthful diet as a precursor to getting what it wants?

I ask this because when I was younger, I also had tastebuds warped by hyper-palatable foods, but after incrementally getting my diet to such a clean and optimized place, I literally feel bad even while chewing and tasting something like a donut, heavily salted and oiled potato chips, or candy. It's probably like how I would have felt if I literally mixed a tablespoon of oil and sugar or salt together and swallowed it.

Is it that hard to shift the system toward better habits by incremental introduction of better ones, and crowding out the bad? Exercise helps here, because once you begin to enjoy fitness, you get a stronger feedback loop with the bad food creating bad outcomes.

replies(2): >>Fire-D+yl1 >>shadow+fa2
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79. toomuc+Fh[view] [source] [discussion] 2025-12-21 21:56:09
>>AaronA+B9
Willpower is just brain chemistry. Some are lucky, some are not.
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80. lr4444+ii[view] [source] [discussion] 2025-12-21 22:00:07
>>asciim+h7
As someone with asthma, let me tell you that they _do_ need to get into better shape to breathe better. Part of that is a medically proven practice called pulmonary rehabilitation, but also, regular cardiovascular exercise at different intensities and direct training of the abdominal muscles has a marked improvement both on pulmonary function (to a limit, but even more important as you age) and oxygen utilization from the reduced pulmonary function. Finally, both acid and laryngeal reflux are silent contributors to asthma by introducing acid and pepin into the airways, and weight loss can improve the symptoms of those.
replies(1): >>diziet+uT
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81. george+ak[view] [source] [discussion] 2025-12-21 22:11:03
>>jchw+68
Entirely anecdotal, perhaps useless information (and off-topic for anyone who doesn't current consume caffeine) but I've never had an easier time losing weight than I have since I entirely quit using caffeine after decades of normal usage.

After eliminating caffeine its like a switch entirely flipped in my brain turning off all the usual cravings I'd have for carbs/sugars/etc.

The quitting caffeine part was pretty horrible though. Not just because of the headaches (which weren't actually super bad for me) but I went through a couple of weeks of what I assume was for-reals depression/anhedonia as my brain figured out how to operate with non-blocked adenosine suddenly suppressing my dopamine levels.

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82. pton_x+2u[view] [source] [discussion] 2025-12-21 23:27:09
>>jchw+68
> "Just Eat Less" is roughly the way to lose weight

Maybe the messaging should be "eat healthier"? How many obese people cook for themselves and eat exclusively from the outer aisles of the grocery (fruits, vegetables, seafood, meat, eggs, dairy)?

I could be wrong but I have to imagine the average obese person has a terrible diet. Portion control won't work at that point, you're already doomed to fail.

To be fair, most people have a terrible diet, it's just that some lucky individuals have the metabolism to overcome it. It seems like those people are increasingly the exception and a bad benchmark for how humans should eat.

replies(1): >>nradov+nF
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83. busyan+fu[view] [source] [discussion] 2025-12-21 23:29:07
>>AaronA+B9
What is your definition of willpower? What is it, mechanistically, that you have and others lack?
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84. pupppe+Ow[view] [source] [discussion] 2025-12-21 23:54:58
>>jmward+95
But what if these weight loss drugs are making you hungrier than you ever would have been had you not started in the first place?
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85. true2o+sy[view] [source] [discussion] 2025-12-22 00:14:26
>>skrebb+y7
Particularly eating a lot of eggs daily for about 3 years
replies(1): >>nradov+GF
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86. true2o+az[view] [source] [discussion] 2025-12-22 00:19:39
>>paulpa+yd
It takes time and discipline to make the stomach smaller

I was pre-diabetic at 100kg and went down to 70kg over a year of low carb diet and intermittent fasting

It’s a daily struggle trying to NOT eat until literally feeling pain in the belly, and even then, I know if I wait 30 minutes more I can keep eating

replies(1): >>array_+oH2
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87. milch+JB[view] [source] [discussion] 2025-12-22 00:48:26
>>diziet+E8
I find for me that doesn't work. I have to actively count calories to lose or maintain a healthy BMI range. If I don't, no matter what I eat, I end up stabilizing in the overweight category. I'm lucky enough that my wife has a very flexible work schedule where she is able to cook most meals for us, but she hates weighing everything out so I can track... we've tried to stop the tracking multiple times but it never works. I'll think I'm eating to the same satiety level as before, but I end up slowly creeping back up in weight. My wife is fine either with or without tracking for maintaining her weight, though she does also seem to have an easier time losing when she's counting her calories. I think this is why it's so hard to have discussions about it, people's experiences literally don't match even when they try the same things. I suspect I'd be one of those people that if they tried Ozempic would be able to lose tons of weight, and who would shoot back up as soon as they stopped, unless I track the whole time... at which point I wouldn't need the Ozempic in the first place
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88. nradov+zD[view] [source] [discussion] 2025-12-22 01:09:08
>>jmward+95
I doubt that willpower or lack thereof is a significant factor. It's more a matter of habits and discipline. Willpower can allow you to resist temptation for a few hours but it's not sustainable.

I know several people who were formerly obese and have achieved sustained weight loss without drugs or surgery. The common factor seems to be that they "hit rock bottom", sort of like a drug addict, and decided to make permanent lifestyle changes in order to survive and stop letting down those who depended upon them. These lifestyle changes are often pretty drastic, and involve more than just eating less and exercising more.

If people want to take GLP-1 drugs and understand the risks then I have no problem with that and don't see it as a moral failing. But they might want to evaluate whether this is just masking the symptoms of some deeper mental health condition.

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89. nradov+OD[view] [source] [discussion] 2025-12-22 01:12:54
>>paulpa+Oc
Why would we think that? Tolerating discomfort seems to be a skill that anyone can develop with deliberate practice. Perhaps genetics imposes some upper limit, but just like in sports most people never put in the work necessary to even approach their genetic limit.

https://eastermichael.com/book/

It's winter in the Northern hemisphere right now. Try going for a walk tomorrow deliberately undressed to the point that you're deeply uncomfortable but not risking serious injury or death. Anyone can do this, and over time it makes tolerating other forms of discomfort easier.

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90. DamnIn+8F[view] [source] [discussion] 2025-12-22 01:26:27
>>AaronA+B9
Oh, you can't reach the items on the higher grocery shelves no matter how hard you stretch? That's just a deficit of tall-power. I also experience items on high shelves. No, you shouldn't use a stepping stool to grab those items; just stretch more, and grow taller, like me! Look how good I am at being a bit taller than you! Your failure to be slightly taller is a character flaw, feel bad.
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91. nradov+nF[view] [source] [discussion] 2025-12-22 01:28:38
>>pton_x+2u
Differences in metabolism are very seldom the real reason. The people who claim they have a "slow" or "fast" metabolism can't back that up with actual RMR test results. They're just bad at estimating many calories they actually consume. This can go both ways.
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92. nradov+GF[view] [source] [discussion] 2025-12-22 01:34:37
>>true2o+sy
The Time Magazine cover story in 1984 where they falsely claimed that consuming cholesterol from eggs and other sources was dangerous was a real turning point. That misunderstanding has caused tremendous harm to public health for decades. I think the journalists acted in good faith but they believed junk science.

https://time.com/archive/6855517/hold-the-eggs-and-butter/

https://content.time.com/time/specials/2007/article/0,28804,...

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93. pandam+3G[view] [source] [discussion] 2025-12-22 01:39:16
>>paulpa+7c
If normal resistance to weight gain or appetite lead to 35+ BMI then we would not have had the obesity epidemic, it would be just normal state for humans to be 200+ lbs weight just like it's normal to be under 7' height.
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94. nradov+cG[view] [source] [discussion] 2025-12-22 01:40:57
>>asciim+h7
Some people have literally been able able to overcome asthma — or at least significantly reduce symptoms — by learning to breathe better. Getting in better physical shape can be part of this. That doesn't necessarily work for all patients but at least some have been successful.

https://www.penguinrandomhouse.com/books/547761/breath-by-ja...

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95. diziet+uT[view] [source] [discussion] 2025-12-22 04:21:18
>>lr4444+ii
Thank you for sharing this and elaborating on what I've seen firsthand. Another thing we've noticed is that an increase in VO 2 Max, which does take quite a bit of time to change, makes a major difference.

Altitude is another factor, due to dry and colder air and lower oxygen -- a double whammy for asthma.

replies(1): >>lr4444+OG4
96. daft_p+LT[view] [source] 2025-12-22 04:23:54
>>neom+(OP)
I basically just gained the weight back again.

I missed doses long enough that I had to start at the beginning, but I avoided that because I had to book and appointment with my doctor and get prescribed the lower dose, etc.

So I gained the weight all back and then lose it again when I got back on the doses.

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97. seba_d+OV[view] [source] [discussion] 2025-12-22 04:55:01
>>AaronA+B9
I don't think my ability to sit with hunger without fainting or experiencing massive headaches is due to my willpower. Fortunately, at least I'm not ignorant about it and don't write comments like yours.
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98. thefz+h31[view] [source] [discussion] 2025-12-22 06:37:01
>>AaronA+B9
You can't make this point here without getting down voted to oblivion.

I know many ultra endurance runners and they are all in very good - healthy - shape. The only thing they all have in common is that they are very, very disciplined people.

replies(1): >>array_+PE2
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99. thefz+s31[view] [source] [discussion] 2025-12-22 06:40:14
>>manmal+3c
Insulin sensitivity is made better or worse with diet alone
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100. sergio+R91[view] [source] [discussion] 2025-12-22 08:40:24
>>thefz+hd
No. The article explains they do not cure the underlying issue, whatever it is. We have many such drugs, widely accepted as safe and effective.
replies(1): >>thefz+Gf1
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101. thefz+Gf1[view] [source] [discussion] 2025-12-22 09:45:15
>>sergio+R91
So they are not effective.
replies(1): >>array_+OF2
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102. Fire-D+yl1[view] [source] [discussion] 2025-12-22 10:43:48
>>lr4444+Ah
Yes, I gained weight anyway. Sad, I hoped that was going to be my fix.

Also, not everybody enjoys fitness.

I don't like it. I still go 5 times per week and have been doing it consistently for the last 2.5 years

I'm muscular, a bit overweight.

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103. xorcis+XA1[view] [source] [discussion] 2025-12-22 13:34:12
>>paulpa+Oc
Metabolism also isn't immutable. Ask anyone who became vegetarian for example.
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104. xorcis+QC1[view] [source] [discussion] 2025-12-22 13:50:45
>>jmward+95
> society views being fat as a moral failing

This is just as weak as a counter argument. If every argument that concludes that lifestyle changes are necessary, in most situations and for most patients, are just written off as some sort of moral high ground and not necessarily something to take seriously, then what do we have left?

Is there seriously no functional difference between healing a broken bone and getting someone to stop smoking? The only problem is just that we haven't found the right medication for the latter? Evidence of necessary lifestyle changes as part of some moral crusade?

The science is pretty clear on the subject and it is up there as one of the most well studied in medicine. Yes, anyone can stop smoking and anyone can gain or loose weight. Yes, lifestyle changes are the most imporant factor in a treatment being successful.

replies(1): >>array_+wC2
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105. shadow+D82[view] [source] [discussion] 2025-12-22 17:11:24
>>AaronA+B9
>I experience that and just sit with it. That is the difference.

Other people might have it worse and it might stay with them longer.

Could you keep it up if you were 10x as hungry as you are now for next 5 years?

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106. shadow+O92[view] [source] [discussion] 2025-12-22 17:17:22
>>paulpa+Ue
Something like less then 2% of people keep weight off for more then a year from dieting alone
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107. shadow+fa2[view] [source] [discussion] 2025-12-22 17:19:09
>>lr4444+Ah
One of my friends ate two pounds of tomatoes every evening and would not feel full. I couldn’t believe it until I saw it with my eyes….
replies(1): >>iteria+FY2
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108. uxjw+qi2[view] [source] [discussion] 2025-12-22 18:00:11
>>isopro+36
Yes, the cheap engineered "foods" don't help, and they're everywhere. This part of the article really hit home:

> He is worried that without additional support for people making the transition, society's unhealthy relationship with food means little will change.

> "The environment that people live in needs to be one that promotes health, not weight gain.

Also generic versions of Ozempic are coming to Canada soon: https://www.cbc.ca/news/health/ozempic-generic-canada-weight...

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109. array_+wC2[view] [source] [discussion] 2025-12-22 19:35:40
>>xorcis+QC1
There's a common misunderstanding that medication and lifestyle changes are two separate things, and we should do one or the other, with medication being the "easy way" out.

No. The way GLP-1 drugs work is by lifestyle changes. People on GLP-1 agonists will, on average, eat smaller portions, are more inclined to eat healthier food, and will even exercise more.

If you take GLP-1s and don't do the lifestyle changes, they don't work. So are these drugs useless? No. They make the lifestyle changes more attainable. In your smoking example, it's similar. We have cessation drugs, I know because I've used them. No, they don't magically make you stop smoking. But they do make it easier.

We need to rewrite how we view these drugs. They don't take away your power, your strength. No, they help you find it. You had the strength all along, but these are tools to help you exercise it.

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110. array_+eD2[view] [source] [discussion] 2025-12-22 19:38:43
>>tartor+Wb
> Taking Ozempic also drops a lot of muscular mass and that ozempic face look totally makes sense.

No, it doesn't, weight loss does this. I've lost weight before via starving and even as a man, all my muscle went poof. If you look at someone like Ariana Grande, who clearly is anorexic, here arms are like sticks and here face looks tautly stretched over her bones.

This is just what happens when you starve your body of nutrients. Your muscles are some of the first to go because they're the least vital. Your organs and brain are much, much more important. Your body will have no issue taking your muscle away to give it to your organs. Regardless of ozempic.

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111. array_+VD2[view] [source] [discussion] 2025-12-22 19:42:05
>>AaronA+B9
> But it is factually true that it’s a matter of willpower, no amount of reframing it is going to change that.

Okay... how?

You can't just make incredibly bold claims, say "it's a fact!" and then move on. No, you have to back them up otherwise you're just a bullshitter.

I don't know what other people, anyone else, is feeling. How do I know my hunger is their hunger?

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112. array_+PE2[view] [source] [discussion] 2025-12-22 19:45:37
>>thefz+h31
> I know many ultra endurance runners and they are all in very good - healthy - shape. The only thing they all have in common is that they are very, very disciplined people.

Right, but are you not seeing that this is orthogonal?

Meaning, is it that running MAKES YOU disciplined, or rather that people who are already predisposed to being disciplined are more likely to be runners? This says nothing about the genetic component of it.

And you would have to be born yesterday to truly think there is no genetic component. Even with alcoholism, we know it's hereditary. We know when it comes to compulsions there is a genetic component. This is not opinion, this is fact. We know this.

But specifically with food habits, you truly believe this is not the case? Do you not see how incredibly bold of a claim that is? How atypical, how surprising, that would be?

I'm not saying that some people are blessed and some are not. Everyone has the power to change their lives. But I AM saying that it's not the same for everyone. From the beginning, I have known some things come easier to some people. I thought this was common knowledge, a part of the human condition we were all aware of.

replies(1): >>thefz+qG5
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113. array_+OF2[view] [source] [discussion] 2025-12-22 19:48:55
>>thefz+Gf1
Are you not listening or...?

I took chemotherapy for cancer treatment, and it was very effective. Chemo is not a root-cause solution. It's a shotgun solution, a hammer even. It just kills cells that look like cancer. It doesn't stop cells from being cancerous, or turn cancerous cells back into normal cells. It's also carcinogenic, meaning it actually causes cancer. I am now much more likely than the general population to develop another cancer.

But it also saved my life. We do not measure effectiveness of medicine by if you think it's morally just. Nobody cares what you think, actually. We measure it in the real world, by if it works.

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114. array_+RG2[view] [source] [discussion] 2025-12-22 19:53:44
>>paulpa+id
It should also just be obvious to people. The body, of course, has a choice in how it spends it's energy.

There have been studies on ababolics, synthetic testosterone, that demonstrate this. Taking steroids and doing absolutely nothing leads to more fat loss and more muscle gain than not taking steroids and working out. Which... yeah duh.

But people will still deny this, because of the implications. We all have different baselines, and nobody likes to hear that they got lucky in some ways. Everyone wants to believe the world and human condition is perfectly fair, so they feel that they deserve what they have.

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115. array_+oH2[view] [source] [discussion] 2025-12-22 19:56:15
>>true2o+az
> It’s a daily struggle trying to NOT eat until literally feeling pain in the belly, and even then, I know if I wait 30 minutes more I can keep eating

Yes, but this is sort of the point. If we can make it not a daily struggle, probably a lot more people would be successful.

Generally, I think the solution of "just suffer" is a bad one. If people's solution requires a certain amount of pain, it's probably just a suboptimal solution, and we can do better.

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116. array_+sI2[view] [source] [discussion] 2025-12-22 20:01:26
>>sixtyj+s8
> one has to ask what is behind it.

The human body is stupid and makes a lot of mistakes. It's very obvious to me that our bodies and minds were not built for their current environment.

When someone's brain has a bug in which is has seizures, we do not ask them "what's behind" their epilepsy medication. No, we understand their brain has a problem that should be fixed. There is no ulterior perspective, some secret hidden ability they might possess. It's just bad.

But when it comes to food, we forget this is how we view things. In it's place comes moralizing.

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117. iteria+FY2[view] [source] [discussion] 2025-12-22 21:26:22
>>shadow+fa2
I feel like they should try the potato diet. I recommend it, not because I believe it is effective (it wasn't for me), but because it is very good at removing the pleasure from eating. When you are eating to survive, you will come to understand how what being sated is. From there, I found I could lose weight because I had broken the habit of eating for any other reason than to fuel myself. Although, admittedly, I enjoyed losing weight this way better than the potato diet.

With some people, I think they have just lost what being sated feels like.

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118. metalm+Jn4[view] [source] [discussion] 2025-12-23 12:16:04
>>Throwa+ga
then, get some real farm fresh eggs, and an incubator or whatever, close the old not working chapter,and if you are feeling nostalgic, you can pause for a moment to warm your hands on your burning bridges. we live in a vast sea of excess everything but thinking about it, realy quitting sugar will have profound effects on your sense of taste, and things formerly acceptable can become quite disgusting, and others that were marginaly edible become wonders of taste and delecacy. It is shocking how fantastic varios fruits and vegatables can taste, beyond taste!, when eaten in the field, but only if white crystaline substances are eliminated and purged from your diet. keep in mind, that white crystaline substances, are absolute.There is NO further concentration or enhancement possible,and nature has never saw fit to create such things organicaly, and almost every other white crystaline thing is totaly inert or highly regulated and/or illegal to possess.
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119. lr4444+OG4[view] [source] [discussion] 2025-12-23 15:10:23
>>diziet+uT
People also are often unaware that the symptoms of asthma which cause the most concern (dyspnea, tightness, etc.) are less hypoxia and more hypercapnia. Hypoxia in normal people does not feel like breathlessness: it's lightheadedness, low energy, turning blue, etc. Asthma is almost definitionally airway hyper-responsiveness (and relevant structural changes): any fitness intervention that can help improve CO2 expulsion will probably greatly help an asthmatic seek relief. This is also why in acute attacks, pursed lip exhalations can really help.
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120. thefz+qG5[view] [source] [discussion] 2025-12-23 21:30:15
>>array_+PE2
Ultimately the decision to put food or alcohol in your mouth is yours. I am tired of hearing of external factors, let's bring it back to the individual.
replies(1): >>array_+Zrd
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121. array_+Zrd[view] [source] [discussion] 2025-12-27 06:04:56
>>thefz+qG5
This view is held by many because it's incredibly simplistic and naive, while simultaneously allowing people to gain moral leverage. Meaning, if everything is in our control, then if we do good, we must be very good.

But it's just obviously not true. From the beginning, it is clear life is unfair. Children die from cancer. Are they losers? Should they have ate more veggies?

When everything happens for a reason, that has some unsavory side effects. This is all philosophical, but also real.

We are an amalgamation of what is in our control, and what is not. I could sit here and pat myself on the back for being skinny and attractive. Really, I could. But does that not seem, maybe, a bit pathetic?

I did have something to do with it, but it was not all me. I shouldn't take all the credit, and frankly I don't need it. Maybe some people do need it, in which case they should do other things to be proud of. There's no pride in being proud of something you did not achieve.

I think, for both you and me and for most things in life, the reality is that most things were given to us. Yes, we have achieved - off the shoulders of giants. Whether that be genetics, time, place, family.

From there, we have a few options on how to view the world:

- conclude that, since we've achieved nothing on our own, we must be losers, and kill ourselves.

- denounce the notion, and live in the delusion that we did do it all on our own. Essentially, lie at a fundamental level to boost our ego. Is there a lower low a person can sink to?

- embrace humility, and acknowledge that we are blessed and favored. Acknowledge that we do not know it all, and that our success is based off of practically infinite random things going right in our favor.

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