zlacker

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0]

The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consumed. Revita basically re-surfaces the duodenum.

So, the idea is that you get to a lower weight with the GLP-1 drugs, and then Revita can hopefully reset your set point there.

Their first clinical trial is still in progress, but I think it's interesting to watch.

[0]: https://www.fractyl.com/our-platforms/revita/

>>Taikon+(OP)
Surprised this is still in first trial. I can recall reading about something like it in 2017. Apparently clearing the duodenal mucosa is a preparatory step for a gastric band fitting, but they found patients were making improvements before the bands were being fitted so a study was started to see if this less invasive procedure might be enough by itself.

>>Taikon+(OP)
> Revita basically re-surfaces the duodenum.

Does this reduce mucous production going forward? Otherwise, it seems like it would be a temporary effect.

>>hamand+E3
My impression (and I'm not a scientist) is that the mucosal overgrowth comes from eating an obesogenic diet. (Some combination of too much sugar / salt / wrong types of fat?)

If you get the procedure and don't go back to an obesogenic diet, then it should be permanent.

>>Taikon+(OP)
Fascinatingly, the body already has a mechanism for this: fasting. One of the many beneficial side effects is rapid mucosal atrophy, decreasing villus height and crypt depth.

You can find evidence of this in the literature, but it’s absurdly understudied, because big pharma would rather sell you a subscription to life.

Fortunately there are many good people in the world, especially in the field of medicine, who want to help their patients unconditionally. So there are glimmers of hope, like some of the top cardiologists in the world going against status quo and treating patients with fasting regimes instead of surgery.

>>refibr+y9
Do you have some good links for that? I only found this

https://www.mdpi.com/2072-6643/16/1/128

which says that the changes reverted quickly after resuming normal feeding

>>Taikon+(OP)
https://en.wikipedia.org/wiki/Duodenum

Fascinating.