>>neom+(OP)
Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0]

The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consumed. Revita basically re-surfaces the duodenum.

So, the idea is that you get to a lower weight with the GLP-1 drugs, and then Revita can hopefully reset your set point there.

Their first clinical trial is still in progress, but I think it's interesting to watch.

[0]: https://www.fractyl.com/our-platforms/revita/

>>jeffbe+d8
> (British) A medical hypodermic injection (vaccination or inoculation).

From https://en.wiktionary.org/wiki/jab

I hope that helps

>>refibr+ff
Do you have some good links for that? I only found this

https://www.mdpi.com/2072-6643/16/1/128

which says that the changes reverted quickly after resuming normal feeding

>>Taikon+H5
https://en.wikipedia.org/wiki/Duodenum

Fascinating.

>>paulpa+Oc
Why would we think that? Tolerating discomfort seems to be a skill that anyone can develop with deliberate practice. Perhaps genetics imposes some upper limit, but just like in sports most people never put in the work necessary to even approach their genetic limit.

https://eastermichael.com/book/

It's winter in the Northern hemisphere right now. Try going for a walk tomorrow deliberately undressed to the point that you're deeply uncomfortable but not risking serious injury or death. Anyone can do this, and over time it makes tolerating other forms of discomfort easier.

>>true2o+sy
The Time Magazine cover story in 1984 where they falsely claimed that consuming cholesterol from eggs and other sources was dangerous was a real turning point. That misunderstanding has caused tremendous harm to public health for decades. I think the journalists acted in good faith but they believed junk science.

https://time.com/archive/6855517/hold-the-eggs-and-butter/

https://content.time.com/time/specials/2007/article/0,28804,...

>>asciim+h7
Some people have literally been able able to overcome asthma — or at least significantly reduce symptoms — by learning to breathe better. Getting in better physical shape can be part of this. That doesn't necessarily work for all patients but at least some have been successful.

https://www.penguinrandomhouse.com/books/547761/breath-by-ja...

>>isopro+36
Yes, the cheap engineered "foods" don't help, and they're everywhere. This part of the article really hit home:

> He is worried that without additional support for people making the transition, society's unhealthy relationship with food means little will change.

> "The environment that people live in needs to be one that promotes health, not weight gain.

Also generic versions of Ozempic are coming to Canada soon: https://www.cbc.ca/news/health/ozempic-generic-canada-weight...