The highest probability is this virus originated like every other virus in history.
If an outbreak were to happen in the United states just about everywhere would be near a CDC location: https://www.google.com/search?client=firefox-b-e&tbs=lf:1,lf...]
If there were more evidence that it was lab made then the location would be another point, not to me without further evidence it doesn’t mean all that much.
And there have been 2 emerging coronavirus outbreaks in the last 20 years due to natural origin. Why is it so hard to believe there would be another one.
This is an argument from incredulity.
Have you actually read any of these articles? The location of the lab is like the tip of the iceberg.
I’m not saying it is impossible, just unlikely. And automatically degrading the opinions of experts who have detailed their arguments because you think they are biased is not proof of anything either.
You've artificially limited the number of possible labs to those doing bioweapon research. If this isn't your claim there is no reason to do so and if there are more labs studying coronavirus it's far less coincidental.
But again, you really should read the article to understand what gain of function research is instead of insinuating I said COVID was a bioweapon.
Honestly, this is not a difficult distinction to understand. You have to wonder why people are so eager to conflate the two.
In any case, beyond gain-of-function, the WIV and Wuhan CDC also had the biggest program in the world to sample novel SARS-like coronaviruses from nature, from remote bat caves that no other humans had any reason to enter.
https://www.washingtonpost.com/world/asia_pacific/coronaviru...
If SARS-CoV-2 is a naturally-evolved virus accidentally released by scientists, then Wuhan is the obvious place for it to emerge. That could have been directly from a lab, or a researcher could have become infected on a sampling trip, traveled home from the sampling sites (~900 miles away, to be clear; Wuhan was not an expected natural spillover region), and seeded the infection there. None of this is anywhere close to proven, but the previous dismissal of any unnatural origin as a "conspiracy theory" was an outrageous, unscientific smear.
For an epidemic to occur, you need not just a lab leak, but a population sufficiently naive to the pathogen. H1N1 was displaced by H2N2 in the late 1950's pandemic, which in turn was displaced by H3N2 in the late 1960s pandemic. Thus it hit the cohort of people aged 25-6 or less who'd never been exposed to H1N1.
For a virus to originate in a city with one of three labs in the entire world conducting heavy-duty researching involving the exact kind of virus that unleashed this pandemic, with the stated intention of working with said viruses to make them more infectious (NOT for the purposes of making a bioweapon) that deserves special consideration. Especially with the fact that the animal the virus is thought to come from ranges 1500 miles south from said city, and started during a time that animal is typically hybernating.
How do I square that with this claim from the article?
> Eleven of its 23 coauthors worked for the Academy of Military Medical Sciences, the Chinese army’s medical research institute. Using the gene-editing technology known as CRISPR, the researchers had engineered mice with humanized lungs, then studied their susceptibility to SARS-CoV-2. As the NSC officials worked backward from the date of publication to establish a timeline for the study, it became clear that the mice had been engineered sometime in the summer of 2019, before the pandemic even started. The NSC officials were left wondering: Had the Chinese military been running viruses through humanized mouse models, to see which might be infectious to humans?"
What this describes seems like it could be circumstantial evidence of the PLA developing bioweapons. Certainly it isn't proof of anything, and as evidence it's not very strong. But I wouldn't call it 'zero.'
The WIV and Wuhan CDC sent grad students to hike through the wilderness to remote bat caves too far from any road or farm to have been exploited yet for any practical use. They chose those caves based on their expert predictions of where they expected to see the greatest diversity of novel coronaviruses.
There's obviously far fewer WIV grad students than guano harvesters; but the risk per person seems orders of magnitude higher, for an expert deliberately seeking a virus vs. a merely indifferent laborer. So that seems like a new and non-negligible risk to me, and thus one that requires investigation. Note that I'm not alone in this; Marc Lipsitch, for example, often mentions this possible pathway.
That's one of the independent vectors the author mentions that makes so many of us suspect very specifically a lab leak of a gain of function experiment: the virus started out very well adapted to humans.
https://www.pnas.org/content/102/23/8073
So if the Chinese military had in fact been doing this, I'd guess it was just basic research, in the same way that lots of American basic research links back to DARPA. Of course they fund it because they believe there might be a military application, but I see no reason to think that application would be bioweapons (vs. the same kind of beneficial applications described in the open literature).
Why is this relevant unless you're claiming that the virus that we've observed has been engineered in that way? Otherwise it seems like the chance of a coronavirus outbreak caused by poor handling in a lab is the same for any lab that's studying them for any purpose.
This one was, yeah, this is a virology institute, we study corona viruses, we were hiring for corona virus experts, we do GoF work, but trust us, just because it first appeared blocks from our facility, it did not come from us. Also, don't believe our former virologists who skipped town.
Most virologists say the way this virus works is unlike anything they’ve seen or expected so they can’t imagine how a human would have engineered it. Why do you think your feeling about the virus’s level of adaptation trumps the experts opinions?
I found an NIH article that says the likelier origin is that the 1950 virus was used to produce a weakened live virus vaccine candidate that lead to the reemergence and not an accidental leak. It also concludes by saying there has never been a likely lab leak epidemic ever observed.
> Of 23 samples that came from Wuhan, only three were type A, the rest were type B, a version two mutations from A. But in other parts of China, Forster says, initially A was the predominant strain. For instance, of nine genome samples in Guangdong, some 600 miles south of Wuhan, five were A types. [0]
[0] https://www.usnews.com/news/best-countries/articles/2020-05-...
It's a long article so I don't expect you to find the argument in it; it highlights the work of Alina Chan who compared a fast mutation rate of SARS-CoV as it better adapted itself to human to SARS-CoV-2. Here are titles of three of them I've saved but not read, May through September of last year:
SARS-CoV-2 is well adapted for humans. What does this mean for re-emergence?
Single source of pangolin CoVs with a near identical Spike RBD to SARS-CoV-2
COVID-19 CG: Tracking SARS-CoV-2 mutations by locations and dates of interest
Is that really so for animal-borne viruses though? I thought they came from place with lots of animals, hence the focus on the market. If it just showed up on some random high-rise employee downtown that would be hard to believe.
And after it starts, of course a highly-infectious virus shows up at densely populated places quickly. But for the same reason, I would also think it's hard for the first cases to travel to dense areas and spread the disease there without leaving a trail of cases along the trip. Ultimately they should point back to the animals they came from and testing can confirm it. Or at least rule various places out, if the govt was accommodating.
Plus wasn't the first US case somewhere in Washington state.
They don't seem like obvious candidates to me, though. Both SARS v1 and SARS-CoV-2 show unpredictable, stochastic person-to-person spread, via super-spreader events. For a bioweapon that would ideally infect all the enemy but no one else, that's the last thing you want, hard to reliably get started and hard to reliably stop once it starts. So that reinforces my belief that if SARS-CoV-2 was of unnatural origin, it was almost certainly an accident during basic research.
In China before there was a huge outbreak there is absolutely no way you can expect a small number of cases of a virus that nobody knows exists to be picked up. By the time of the big Wuhan outbreak there are already different variations in the virus. It had been in some population for a while before it broke out.
So the first outbreak in NYC is analogous to Wuhan. It could have started in Wuhan or it could have started anywhere else and then Wuhan had the right combination of factors for the outbreak to surge. We don’t know for sure.
I mean sure, anything’s possible, but we have only circumstantial evidence right now and this observation isn’t a smoking gun, but it ain’t worth nothing.
A small number of SARS infections in 2003-2004 are also believed to have been due to laboratory accidents [2].
This article [3] gives an introduction to the subject from the perspective of a journalist who has reported on laboratory safety in the US.
This article [4] published in Nature in January 2012 by members of the US National Science Advisory Board for Biosecurity reviews the risk of a release of an engineered form of H5N1 influenza. It includes some alarming remarks such as:
'We found the potential risk of public harm to be of unusually high magnitude' and;
'A pandemic, or the deliberate release of a transmissible highly pathogenic influenza A/H5N1 virus, would be an unimaginable catastrophe for which the world is currently inadequately prepared'
The authors take the possibility of release of a dangerous pathogen from a laboratory seriously, though the article is prospective rather than retrospective.
[1] https://en.wikipedia.org/wiki/2007_United_Kingdom_foot-and-m...
[2] https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndr...
[3] https://eu.usatoday.com/in-depth/opinion/2021/03/22/why-covi...
Those details do inform some details of the correct policy response. For example, they determine the relative importance of better PPE at the bench vs. better QA before allowing the vaccine to leave the lab. They don't change the overall question of whether scientific research has ever caused a pandemic, though. That causality is what matters, not whether the sign on the door said "lab" vs. "experimental vaccine nurse".
For example, if the pandemic originated from a WIV researcher who became infected in the field (during their many expeditions to remote bat caves that no other humans would routinely enter), was that a "lab leak"? Literally no, since they weren't in the lab. The causality would still be the same, though--if not for that scientific research, that virus would likely have never left the cave.
To avoid such confusion, it's probably better to say something like "unnatural origin", or "origin arising from scientific research". A much bigger mouthful than "lab leak", though.
The article's abstract opens with the statement 'The 1977-1978 influenza epidemic was probably not a natural event'.
It's not hard to believe that there could be another spillover event, and I don't have any certainty where covid-19 came from, but you're unfairly downplaying the level of circumferential evidence that does exist. There has been a significant effort against evaluating the lab-leak as a reasonable hypothesis (I say that in the scientific meaning of the word), and that effort has significantly damaged the reputation of scientific institutions around the world, and for good reason.
This is literally not true.
Most virologists say the way this virus works is unlike anything they’ve seen or expected so they can’t imagine how a human would have engineered it. Why do you think your feeling about the virus’s level of adaptation trumps the experts opinions?
1) Citation on "most" please. The world is a big place, so you will be able to find a citation for any opinion. If you are going to say "most" then please back it up with a source.
2) gain-of-function research doesn't require a human to engineer a new virus. It is a way to essentially speed up evolution and allow nature to do the heavy lifting. You're arguing points that no on here is making.
SARS after all was found in civets, and then later several other species as well despite originating in bats.
I'm not saying you should calculate it like P(10 000 tails coin flip) * P(1 000 000 tails coin flip). That can be done numerically. I'm saying that based on everything I've read, the highest probability hypothesis according to my own evaluation is the unintentional lab leak. To me, that's as uncontroversial as it gets. Human error happens _all the time_. Arguing against the lab leak, knowing what we know about China's refusal to allow an actual thorough scientific investigation into it, seems quite a bit more controversial to me.
Labs burn down, medical errors happen, bridges collapse, whatever. That's just reality.
> We have done bat virus surveillance in Hubei Province for many years, but have not found that bats in Wuhan or even the wider Hubei Province carry any coronaviruses that are closely related to SARS-CoV-2. I don't think the spillover from bats to humans occurred in Wuhan or in Hubei Province.
https://www.sciencemag.org/sites/default/files/Shi%20Zhengli...
The closest animal virus to SARS-CoV-2 was found in nature about 900 miles from Wuhan (RaTG13, in Mojiang), closer to Chongqing, Chengdu, Guangzhou, Shenzhen, or HK.
Put differently, if scientists there hadn't been experimenting with monkeys, Ebola Reston wouldn't have entered humans there. We don't absolve exotic wildlife traffickers or farmers of the consequences of their actions in releasing novel, naturally-evolved viruses; so I'm not sure why we'd absolve scientific researchers.
>There are two subclusters of A which are distinguished by the synonymous mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong)
We can’t rule it out, ie. we only have evidence right now to try to make a determination based on the preponderance of evidence, not beyond a reasonable doubt. The story that is emerging is that we may never be able to prove something beyond a reasonable doubt because the debate was quashed for a year by political concerns, institutional biases, and motivated reasoning.