zlacker

I’m a bit confused why would an anti-parasite drug be used now for covid-19

>>rblatz+(OP)
They're looking at it.

>>rblatz+(OP)
There is some evidence supporting its use, e.g. https://www.ncbi.nlm.nih.gov/m/pubmed/32150618/

>>rblatz+(OP)
It should help alleviating the symptoms, but is in no way a antiviral.

There's a phase 3 trial for treating pneumonia associated with coronavirus. This is based on prior work showing anti-inflammatory response in rheumatoid arthritis (https://www.ncbi.nlm.nih.gov/pubmed/8278823).

Note that the trial is happening in China (https://clinicaltrials.gov/ct2/show/NCT04261517), where the barriers of entry and approval are quite low.

>>rblatz+(OP)
There is some evidence it may be useful as a prophylactic to prevent infection, and it is presently undergoing trials.

More reading:

https://www.ncbi.nlm.nih.gov/pubmed/32074550

https://www.recipharm.com/press/recipharm-notes-increased-de...

https://www.elsevier.com/__data/assets/pdf_file/0007/988648/...

https://clinicaltrials.gov/ct2/show/NCT04303507

https://www.pharmacytimes.com/news/potential-pipeline-medica...

https://www.pharmaceutical-technology.com/comment/parallel-e...

>>Amygaz+R6
> After randomization, subjects take hydroxychloroquine 400mg per day for 5 days, also take conventional treatments.

Huh. I'm on 200mg/day for rheumatoid arthritis.

I wonder if I ought to double dose for a while.

>>mirimi+Pw
Sorry for the late reply: I don't see how it would prevent infection. It could be useful post-infection, to prevent complications and inflammation. Compared that with the standard of care right now which is simply observing the patient during their recovering.

There are a fair amount of studies who took the initial in vitro results (i.e. cell culture) suggesting non-specific antiviral activity (at that level coca-cola is also an antiviral, antimicrobial, and antitumoral, by the way), into animal or human, and they just did not pan out, because it isn't an antiviral.

>>Amygaz+f32
Thank you.

I'll ask my rheumatologist about increasing the dose. In case I get infected, have trouble breathing, and can't get hospital care.