zlacker

Then how does ozempic, whose primary mechanism of action is to decrease appetite, work for obese people?

Yes, your body will compensate somewhat for caloric deficit, and yes, when you gain enough fat mass your adipocytes will divide, creating more/stronger hunger signals that encourage weight gain moreso than someone who was never obese.

But your body is not magic. If you feed it a sufficiently low amount of calories, it has to break down energy stores, e.g. fat, to make up the difference in energy requirements.

>>indeci+(OP)
> Then how does ozempic, whose primary mechanism of action is to decrease appetite, work for obese people?

That is a very interesting question.

> your body is not magic.

But it is a complex, highly adaptable system. The simplistic formula of calorie input = output is highly misleading.

> If you feed it a sufficiently low amount of calories

Sure, if you starve yourself, you'll start transitioning to dust pretty soon.

>>mmooss+jW2
Somewhere between obese and dust you'll eventually hit a healthy weight.

https://pmc.ncbi.nlm.nih.gov/articles/PMC2495396/

>>indeci+wX2
That's a report on one person under direct medical supervision. The general consensus, afaik, is that starving yourself doesn't work, at least not more than short term - the weight comes right back.