zlacker

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1. rootus+(OP)[view] [source] 2026-01-13 03:09:31
I don't know that there's a consensus on what the limit really is. Semaglutide is good for about 15%, tirzepatide about 20%, and retatrutide about 25%. Some people don't get that much, some people get a lot more. Personally, tirzepatide got me just over 35%. I never got anywhere near max dose, either, I am what is colloquially referred to as a super responder.
replies(2): >>vladgu+a7 >>jagged+Ye
2. vladgu+a7[view] [source] 2026-01-13 04:40:41
>>rootus+(OP)
Sorry for personal questions please answer any OR none as you feel comfortable

1) How is your energy/stamina following the 35% loss

2) Have you done any dexascans/bodyspecs to measure your lean mass percentage before and after your loss

3) Did you take any steps to reduce the muscle loss?

4) with 35% loss, what BMI are you at?

replies(3): >>jagged+Af >>wincy+5s >>rootus+Tz2
3. jagged+Ye[view] [source] 2026-01-13 06:31:58
>>rootus+(OP)
Super responders unite, I'm down 32% and shooting for 36% before I hit maintenance. I only made it about half way up the dosage chart before I had to back off due to losing too rapidly (!!). I took a 3 month maintenance and am back to losing again, it's been life changing.

The other wild thing is general health improvement - all of my bloodwork has gone from questionable to better than standard - closer to ideal values than I would ever expect. Liver values, cholesterol, lipids, blood pressure, everything. I expected them to improve but not to the degree that they have, my LDL has gone down by 60%. Actuarial tables say it's given me another ~10 years of probable lifespan, and even more if you think in healthspan.

replies(1): >>rootus+XA2
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4. jagged+Af[view] [source] [discussion] 2026-01-13 06:38:40
>>vladgu+a7
Not the original guy, but down 32%, for a point of comparison:

1) Amazing, like being a decade and a half younger

2) Not before, planning one in the next couple months, but I use skinfold and impedance and they say I've dropped from about 48% to ~20% as I've dropped from 272 to 186, lean mass seems maybe 5kg lower than I started with? Less lean mass loss than I expected.

3) Weight bearing exercise and medium-high protein intake (>80g/d)

4) Per above, starting BMI 37.9 -> ending BMI 25.9

replies(2): >>vladgu+Gk >>rootus+qD2
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5. vladgu+Gk[view] [source] [discussion] 2026-01-13 07:35:38
>>jagged+Af
these are amazing numbers -- how long did this loss take?
replies(2): >>jagged+sn >>rootus+QD2
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6. jagged+sn[view] [source] [discussion] 2026-01-13 08:05:08
>>vladgu+Gk
Just over 2 years from end to end, the majority towards the end when I finally got onto the right GLP-1 medication.
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7. wincy+5s[view] [source] [discussion] 2026-01-13 08:53:43
>>vladgu+a7
I also lost 35% body mass, from 318-208 today. It took from September 2024 to beginning of January 2026.

1) amazing, I can actually do things now. I didn’t realize how much I was resting and just not doing anything around the house. I managed to do my work with stimulants but that’s about it.

2) I did a scan and am currently around 110% for with 100% being the baseline for the average male my age, for my muscle mass. I did lose more muscle mass in the 230-210 loss than most of the previous, but I think that’s because I couldn’t ride my bike everywhere as it’s winter time. I had to chug protein shakes while losing weight and do physical therapy for a few body parts, especially my hip and my shoulders as they were easy to hurt. Going to the gym regularly solved this long term.

3) I guess I answered question 2

4) I’m now 27.1 BMI, although my percent body fat is only 18.9%, so I’m not concerned about the number since I have access to a body scanner and can see I’m fine. My visceral fat levels have dropped below concerning levels, which is great.

I also sleep way better, and the heartburn I thought was just a part of life went from “literally every day” to “once or twice a year, and only if I do something I shouldn’t have”.

I was also way more aggressive about just going to the dose and hit 15mg in April of 2025, and have stayed there. I might go for another 10 pounds mostly out of vanity.

replies(1): >>rootus+iC2
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8. rootus+Tz2[view] [source] [discussion] 2026-01-13 19:53:10
>>vladgu+a7
1. I feel wonderful. Things that were hard are now easy, exercise is invigorating instead of exhausting.

2. I have not. Considered it, but locally the scans are expensive and I could not convince myself what I'd do differently if I knew the numbers. My goals would stay the same.

3. I lift weights, but there's no way around it, losing a lot of weight means caloric deficit and I have definitely lost some mass. I'm trying to establish a slight caloric surplus now combined with a heavier focus on lifting-for-growth to see if I can claw back some of what I've lost. I got big enough at my largest (and I am just over 50 years old, which does not help) that now I have a little bit of loose skin on my belly, thighs, and upper arms ... I'm hoping that if I can regain some muscle that I can alleviate much of that. Otherwise I'll get a surgeon to do it.

4. Currently at 25.2. Could lose some more, but happy enough where I'm at and my test results are spectacular now, so I am no longer targeting further weight loss. I still weigh myself but I am now refocusing my definition for success in how I look and feel.

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9. rootus+XA2[view] [source] [discussion] 2026-01-13 19:57:23
>>jagged+Ye
Congratulations! It feels great, doesn't it? I was not quite pre-diabetic, but trending in that direction. Blood pressure elevated (but not quite 'high'), cholesterol and stuff in the sketchy zone. But now ... everything is really good! A1C was 4.9 at my most recent test. Cholesterol great, blood pressure ~115/70 every day now, etc. I went from what felt like a slow but steady decline through middle age and now I feel 20 years younger, the future looks not like decrepitude but way more active and exciting.
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10. rootus+iC2[view] [source] [discussion] 2026-01-13 20:01:58
>>wincy+5s
> the heartburn I thought was just a part of life went from “literally every day” to “once or twice a year, and only if I do something I shouldn’t have”.

I feel this, too. I was on Prilosec indefinitely, gastroenterologist said I have a mild hiatal hernia and that I'll probably be stuck on PPIs forever. But after losing a lot of weight, I was able to switch to occasional Pepcid instead, with Prilosec temporarily if I get tolerant to the Pepcid. The hernia won't heal itself, but taking the pressure off has really reduced the GERD symptoms.

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11. rootus+qD2[view] [source] [discussion] 2026-01-13 20:06:06
>>jagged+Af
Your stats are very similar. I started at something like 274 (though my overall highest point ever was 284 a couple years ago) and now I'm down to 181. It's a huge difference, as you say it's like being 15-20 years younger. Life changing.
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12. rootus+QD2[view] [source] [discussion] 2026-01-13 20:07:39
>>vladgu+Gk
To add my own anecdata, it took me a bit over a year (September 2024 to December 2025) to lose the weight. I averaged about 1.5 pounds a week consistently.
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