zlacker

This one caught my attention.

In 2015 my (now ex) girlfriend was diagnosed with TNBC. I obviously researched the hell out of it to gain as much of an understanding as I possibly could as a non-medical professional as I'm sure anyone would, and most of my reading suggested that it was mostly African American women and youngish white ladies who tend to get this.

As far as I know, she had used permanent die at least once in her early twenties. Thankfully less than a year later and after chemo and surgery, she fully recovered.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783321/

Edit: added space after comma, fixed grammo

>>karim7+(OP)
Sorry to hear this. But are you implying one single use of hair dye could have caused her cancer?

>>manmal+Za
You're rolling the dice every time you do something that increases your cancer risk. Cancer doesn't have some sort of threshold where you get it.

So yeah, it could have caused it. Is it the likely cause? Maybe not.

>>karim7+(OP)
TNBC is not really a direct category of breast cancer. It's a catch all for "any breast cancer that doesn't have one of the main three targettable handles associated with breast cancer"[0]

In many cases, it could even be a cancer "from some other organ" that winds up in the breast and happens to, even by chance (not growing in the breast because it's a favorable environment), grow there.

[0] could explain why TNBC is more common in African American women -- less research done in those populations

>>throwa+gc
> TNBC is not really a direct category of breast cancer. It's a catch all for "any breast cancer that doesn't have one of the main three targettable handles associated with breast cancer"

> In many cases, it could even be a cancer "from some other organ" that winds up in the breast and happens to, even by chance (not growing in the breast because it's a favorable environment), grow there.

That would imply metastasis, would it not? By which, the originating organ of the tumour could be determined by examining the samples from the initial biopsy. The doctor said that in the case of TNBC there is no hormone expression, which makes it differ from other BC types, and why a more aggressive chemo regime is required for this diagnosis.

I was there, at her second-opinion encounter. Nothing was mentioned about it possibly originating from another organ. She had had repeated body scans, blood work, all that one can imagine. I'm not saying you are wrong, I am saying there was not a single mention in any part of the treatment nor received "coping" literature that this could have come from another organ.

>>karim7+(OP)
Viral or environmental triggers are WAY more likely in someone so young.

>>karim7+hw
It doesn't imply metastasis in the way you're thinking about it. Just because a cancer cell has moved once doesn't mean it will aggressively keep moving to other organs.

Honestly doctors won't investigate too hard because the recommended course of action is likely going to be the same.

Anyways the longtime leading TNBC model cell line (which came from an African American woman, IIRC) turned out to be "likely originating from a melanoma".

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515196/

>>manmal+Za
Cancer is a numbers game. Unlike say, blackjack, you only know about certain risk factors. Many are unknown.

With skin cancer, getting a sunburn every two years triples your risk of developing melanoma. With the fairest skin types, even a single severe burn can increase risk if melanoma. Other skin cancers tend to result from constant exposure over time.

I don’t know much about this scenario with hair product. But if you have some other risk factors, it’s not unreasonable that a single exposure may result in a bad outcome.

>>throwa+BC
> Anyways the longtime leading TNBC model cell line (which came from an African American woman, IIRC) turned out to be "likely originating from a melanoma".

Wow, I had to read that several times. I need to read it a few more times I think. Thank you for that.