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1. karim7+un[view] [source] 2023-07-23 18:42:45
>>Impres+(OP)
This one caught my attention.

In 2015 my (now ex) girlfriend was diagnosed with TNBC. I obviously researched the hell out of it to gain as much of an understanding as I possibly could as a non-medical professional as I'm sure anyone would, and most of my reading suggested that it was mostly African American women and youngish white ladies who tend to get this.

As far as I know, she had used permanent die at least once in her early twenties. Thankfully less than a year later and after chemo and surgery, she fully recovered.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783321/

Edit: added space after comma, fixed grammo

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2. throwa+Kz[view] [source] 2023-07-23 19:51:36
>>karim7+un
TNBC is not really a direct category of breast cancer. It's a catch all for "any breast cancer that doesn't have one of the main three targettable handles associated with breast cancer"[0]

In many cases, it could even be a cancer "from some other organ" that winds up in the breast and happens to, even by chance (not growing in the breast because it's a favorable environment), grow there.

[0] could explain why TNBC is more common in African American women -- less research done in those populations

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3. karim7+LT[view] [source] 2023-07-23 22:01:47
>>throwa+Kz
> TNBC is not really a direct category of breast cancer. It's a catch all for "any breast cancer that doesn't have one of the main three targettable handles associated with breast cancer"

> In many cases, it could even be a cancer "from some other organ" that winds up in the breast and happens to, even by chance (not growing in the breast because it's a favorable environment), grow there.

That would imply metastasis, would it not? By which, the originating organ of the tumour could be determined by examining the samples from the initial biopsy. The doctor said that in the case of TNBC there is no hormone expression, which makes it differ from other BC types, and why a more aggressive chemo regime is required for this diagnosis.

I was there, at her second-opinion encounter. Nothing was mentioned about it possibly originating from another organ. She had had repeated body scans, blood work, all that one can imagine. I'm not saying you are wrong, I am saying there was not a single mention in any part of the treatment nor received "coping" literature that this could have come from another organ.

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4. throwa+501[view] [source] 2023-07-23 22:41:27
>>karim7+LT
It doesn't imply metastasis in the way you're thinking about it. Just because a cancer cell has moved once doesn't mean it will aggressively keep moving to other organs.

Honestly doctors won't investigate too hard because the recommended course of action is likely going to be the same.

Anyways the longtime leading TNBC model cell line (which came from an African American woman, IIRC) turned out to be "likely originating from a melanoma".

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515196/

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