It's still clearly referring only to ads that are part of an extension, and AdNauseam obviously doesn't have any so it can't be the reason.
I ctrl+f'd ads to see what else they say, it's almost all in that section that doesn't apply but one thing that came up was "Impersonation or Deceptive Behavior" under Content Policies which contains the wording " Products or the ads they contain also must not mimic functionality or warnings from a user's operating system or browser". I wonder if that could be argued to apply - mimicking click functionality?
I guess they just invented this "single purpose" policy to be able to ban things without coming right out and saying "you're hurting our revenue stream" :)
There must be someone from legal that's advising them not to ever say anything specific about extensions that mess with ads.