Nvidia GPUs, particularly H100s, have a failure rate orders of magnitudes higher than traditional CPU-only hardware. I myself have accidentally melted an H100 during a large-scale training run.
While it’s trivial to replace a broken GPU in the ground, it seems to be infeasible in space during the life of the satellite. Getting a human or robot “fixer” spacecraft to it would likely cost more than the $30K GPU itself.