At that point it might be just easier to convince the model to write JS directly
It's not too hard to compile a C extension for Python to a WebAssembly and bundle that in a .so file in a wheel. I did an experiment with that the other day: https://github.com/simonw/tiny-haversine?tab=readme-ov-file#...
Since the runtime uses standard WASI and not Emscripten, we don't have that seamless dynamic linking yet. It will be interesting to see how the WASI path eventually converges with what Pyodide can do today regarding C-extensions.