I've personally run Gentoo with OpenRC+glibc and OpenRC+musl on my laptop. I assure you ditching systemd was easier than ditching glibc. The OpenRC system mostly just works (tbh thanks to a lot of great work by Gentoo devs). The musl system required probably a couple dozen patches to various packages to get a basic fully working desktop (most of which were relatively straightforward, but still needed manual intervention).