I hope this is tongue in cheek, right? If not, here are some reasons:
1) spreadsheets embed "functions" via macros and macros are often flagged as malicious. Just combining native functions can get pretty complex.
2) in a spreadsheet, everybody sees the input, which is not always ideal
3) data types are controlled by users for the entire column or sheet, which can mess up formulas
I could probably think of additional reasons.
There also are people who use software to guide space rockets, cars, optimise calculation algorithms and more.
My guess is people with background mostly in CRUD don't get how everybody else messes up estimating so badly and people in the innovative task group find it hard to believe sane people would waste their time giving any estimates other than for technically irrelevant business reasons.