I want native programs on my PC, and fewer apps on my phone.
I get all my apps from F-Droid. If I need to use Steam chat or view the menu at Taco Bell, mobile website it is. I am not gonna put their proprietary software on my phone. This also brings up another interesting difference. There is no desktop program for Taco Bell, that would be super weird. I think other comments already addressed that, but a lot of mobile apps are basically just the website.
A game like Luanti or some sort of Tetris is something I'd want native in both places (desktop and mobile). Games in browsers are a mess.