There was a post on HN where someone implemented a new language compiler purely from Assembly, and shows you from nothing to the very end where it looked mostly like a LISP assembly language. It was really neat. Sadly I dont have the buzzwords for Google to find it anymore, used to be able to find the powerpoint slides for it.
I forgot about HLA (High Level Assembly) though I have not used it personally, there were also a few others like C-- as well:
https://en.wikipedia.org/wiki/High_Level_Assembly