Large corporations are able to allocate dedicated FTEs to tackle this and standardise their processes around best practices. Things like the ability to staff "follow-the-sun" rotations that just aren't feasible at smaller scales.
I'm building Rezible (https://github.com/rezible/rezible) to address this. The aim is to provide an "oncall on rails" experience for teams, with best practices encoded into the product for engineers to follow.