A big one I think is the ability to bid for government contracts. There are often calls for proposals for some relatively small, specific piece of work that could be fulfilled by a smaller company, but because the bidding process itself is so arcane, the contract gets awarded to some giant firm that has lawyers and knows how to negotiate the bidding process.
A way to streamline that process to make it fairer and more transparent could be a win for many people - though obviously large established government contractors don't want that to happen.