zlacker

> The brain fragment was taken from a 45-year-old woman when she underwent surgery to treat her epilepsy. It came from the cortex, a part of the brain involved in learning, problem-solving and processing sensory signals.

Wonder how they figured out which fragment to cut out.

>>theogr+(OP)
I imagine they determined the focus of the seizures by electrical techniques.

I worry this might make the sample biased in some way.

>>pfdiet+F6
Imagine all the conclusions being made from a 1cm cube of epileptic neurons.

>>pfdiet+F6
Considering the success of this work, I doubt this is the last such cubic millimeter to be mapped. Or perhaps the next one at even higher resolution. No worries.

>>theogr+(OP)
The manuscript gives some details in the context of the difficulty of obtaining larger useful samples in the future and the difficulty of understanding if a sample is typical or pathological.

>>creer+KH2
A similar dataset already exists in mouse cortex. More are underway in the field.

https://www.biorxiv.org/content/10.1101/2024.03.22.586254v1