If they accelerate the burning of fossil fuels, extract and process minerals on land and in the ocean without concern for pollution, replace large areas of the natural world with solar panels, etc., the world could rapidly become hostile for large creatures.
An ocean die out as a result of massive deep sea mining would be particularly devastating. It's very hard to contain pollution in the ocean.
Same for lakes. And without clean water things will get bad everywhere.
Ramping up the frequency of space launches a few orders of magnitude into the solar system for further resources could heavily pollute the atmosphere.
Microbes might be fine, and be able to evolve to changes, for much longer.
That would still require a lot of equipment potentially but it's there.
Another possibility would be some kind of rogue agent scenario where the program and hide and distribute itself on many machines, and interact with people to get them to do bad things or give it money. I think someone already demonstrated one of the LLMs doing some kind of social engineering attack somewhere and getting the support agent to let them in. Not hard to imagine some kind of government funded weapon that scales up that kind of attack. Imagine whole social movements, terrorist groups, or religious cults run by an autonomous agent.
Actually, I could see that happening.
Maybe it's time to give AGI a chance to run things anyway and see if it can do any better. Certainly it isn't a very high bar.