Nukes and meteorites have very few components that are hard to predict. One goes bang almost entirely on command and the other follows Newton's laws of motion. Neither actively tries to effect any change in the world, so the risk is only "can we spot a meteorite early enough". Once we do, it doesn't try to evade us or take another shot at goal. A better example might be covid, which was very mildly more unpredictable than a meteor, and changed its code very slowly in a purely random fashion, and we had many historical examples of how to combat.