Altman reacts the how Murati answers a question, implicitly suggesting he might have answered it differently. He could have just kept quiet. Whether this is significant is left as a question for the observer, however, in addition to me, the interviewer noticed it and felt the need to comment.
Personally, in this interview I sensed a disconnect between Altman and Murati, possibly others working at OpenAI. Usually Altman is by himself in these interviews; there's no one else from OpenAI. It led me to suspect Altman was telling interviewers what they wanted to hear.