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1. paulmd+(OP)[view] [source] 2023-09-30 17:41:02
> I think it’s a stretch to associate fungal infections with autism.

I think this tends to discount the emerging narratives about the link between gut microbiome and neurotransmitters.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504309/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234057/

https://www.frontiersin.org/articles/10.3389/fcell.2021.6491...

https://www.theatlantic.com/health/archive/2015/06/gut-bacte...

People are not used to this idea that what happens in your microfauna may play this super important role in what happens in your head, but there are already links to things like parkinsons and anxiety/depression.

To me it's not a stretch to associate fungal infections with a neurological disorder or symptom presentation at all, it's a pretty natural extension of the research that's happened over the last 10-15 years. And in several (human) case studies and research scenarios (mice), there is evidence for an actual causal link and not just "people with neurodivergence have fucked up microbiomes" too - treat the microbiome and you treat the parkinsons, or the ASD, and you can induce autism-like symptoms in mice by infecting their microbiome with B. fragilis.

Not a doctor but this does seem like probably the biggest thing people have tended to ignore (studiously, in some cases), that microbiome might play this huge role in things like weight or mental health. 100 years later, we are going to look back at this as an obvious case of science more or less ignoring what was right in front of our faces because it wasn't medicalized yet.

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