zlacker

Common misconception: Most estrogens (particularly phytoestrogens, but also plastics) bind to receptors so weakly, they work more like antagonists in the presence of stronger estrogens (like red meat).

It'd be like trying to do anabolic steroids while your natural testosterone is very high.

>>asmor+(OP)
The endocrine system is complex and involves multiple pathways and feedback loops. A single compound's weak or strong binding affinity to a receptor doesn't provide a complete picture of its physiological impact.

>>awestr+s2
This was not meant to be an exhaustive explainer, rather a single caveat to stop the "all you need is high absolute T and low absolute E" simplification in its tracks.

Receptor saturation (in this case, E1 vs E2; first pass metabolism turns E2 into E1) is something I had to learn out of neccessity because my endocrinologist didn't really do anything beyond loosely following ancient standards of practice (we don't have specialized gender clinics in Germany).