By the way, the Kfz-Zulassungsstelle is allegedly one of the best-organised offices on Berlin. It's all downhill from there.
If you are in possession of the title of the car, yes.
However if you lease a car, the leasing company will just post the lease to the Zulassungsstelle so that you will not be in possession of the title at any time. So it will require you to go there in person.