There are major usability problems, mostly related to graphics (the protocol that forwards the windows is purposefully dumb and doesn't support 3D acceleration at all), but for things like browsing bank apps or even watching youtube it's enough.
This is a major reason I haven't tried QubesOS yet. Thanks to Nvidia I've seen what happens when you run a desktop with a browser without hardware acceleration and it sucks. CPU cores get pegged with basic scrolling or video playback and power consumption is simply unreasonable.
Perhaps if I were a human rights activist or a journalist I would use it, but I'm not.