For a long 6 years, Chrome could not access my website (but all other web browsers can) because it was unable to respect server-side mandatory negotiation of non-HTTP/3 along with only ChaCha/Poly (no AES/RSA). Microsoft Edge fixed theirs shortly afterward.
Happy to say, Google just fixed it (about 4 months ago).
Many free cross-browser testing tools still can demonstrate the breakage (via version testing).