Then the game will switch to encrypted proxied traffic that you cannot block.
Then the adblocking software will switch to the GPU layer, and use machine learning and AI to wipe the region of memory in the GPU containing the ads (and replace it with something benign).
Then the next logical step from likes of google is a fully trusted computing environment - aka, you as an end user no longer control your own machine.
This is entirely predicted by Richard Stallman.