I have five windows open with about 1000 tabs in each, no performance problems at all. It's great!
I find it useful to periodically prune, though. Save to Pocket or other "to read" list for things I intend to eventually read. Bookmark things I may want sometime, but don't need open. Potentially use Tab Stash to save groups of references for particular research tasks. Toss things that realistically I'm just not going to get to ever.