For me, no.
I grew up in the era of internet wild-west and I understand why some of us still feel the need to operate with multiple levels of (perceived) safety even today.
That said, I think most of it is really foolish crap now. The sorts of exploits that are out in the wild that you should actually worry about will go right through defender like a modern bunker buster.
It's really upsetting to me when you think about how much performance/energy/UX latency/frustration/et. al. is being spent in hopes of achieving a minor incremental improvement in security. Windows defender == TSA for your PC.
If you know to not download & run executable files from sketchy websites, you are basically already at the limits of what defender is effectively achieving on your local machine.