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1. DrAwde+(OP)[view] [source] 2023-01-02 17:28:03
Moderna | Entry Level PhD (Scientist) or 1-2y for Sr. Sci | Full-time ONSITE | Cambridge, MA | https://modernatx.eightfold.ai/careers/?pid=309250885374

I am looking for someone with phosphoramidite-based oligo synthsis chemistry experience to start-up a new operation as part of my RNA Chemical Biology team.

Tl;dr - N1-methylpseudouridine is great, but this role presupposes maybe there is something better and I need someone to help us discover/invent it, and CMC/commercialize it.

replies(1): >>v8xi+V
2. v8xi+V[view] [source] 2023-01-02 17:32:15
>>DrAwde+(OP)
Maybe try structural optimization! ;) https://www.nature.com/articles/s41565-019-0517-8 - see the stability optimizations with Spinach
replies(1): >>DrAwde+Gx
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3. DrAwde+Gx[view] [source] [discussion] 2023-01-02 19:53:54
>>v8xi+V
Totally! Thanks for the suggestion : )
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