zlacker

Is folding@home obsolete now?

>>candid+(OP)
Good question… I’d imagine that other methods of folding solutions are still valuable, because AlphaFold needs to be checked.

>>candid+(OP)
I would say no, the two approaches may be used to validate each other.

>>candid+(OP)
Folding@home answers a related but different question. While AlphaFold returns the picture of a folded protein in its most energetically stable conformation, Folding@home returns a video of the protein undergoing folding, traversing its energy landscape.

>>candid+(OP)
It's not, but the question is (and has long been) whether the energy expended by folding@home is worth the scientific result. IMHO- probably not.