zlacker

Same as any other prediction I'd presume. Run it against a known protein and see how the answer lines up. Predict the structure of an unknown protein, then use traditional methods (x-ray crystallography, maybe STEM, etc) to verify.

>>luma+(OP)
This is exactly right.

>>luma+(OP)
As a simple example, one measure used to compare a predicted structure against a reference is the RMSD (root mean square deviation).

https://en.m.wikipedia.org/wiki/Root-mean-square_deviation_o...

The lower the RMSD between two structures, the better (up to some limit).

>>luma+(OP)
"Verify" is almost correct. The crystallography data is taken to be "ground truth" and the predicted protein structure from AlphaFold is taken to be a good guess starting point. Then other software can produce a model that is a best fit to the ground truth data starting from the good guess. So even if the guess is wrong in detail it's still useful to reduce the search space.