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1. lamont+(OP)[view] [source] 2021-06-04 18:44:02
RaTG13 is decades of evolution away from SARS-CoV-2, all over its genome.

You don't get there by splicing an ACE2 spike onto an RaTG13 backbone and passing it through a dozen mice. That gives you something that still looks similar to RaTG13 and infects mice.

The ACE2 spike also looks most similar to a previously unknown ACE2-binding spike protein found in malaysian pangolins.

So WIV would have had to have discovered that pangolin spike-protein, kept it secret, spliced it into an RaTG13 backbone, then not used mice but passed it through a species like that had a human-like ACE2 for a decade and millions of animals.

An alternative hypothesis is that Charles Darwin did that experiment.

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