My partner left finance to work in medicine. She makes a lot less money and likes it a lot better. I dunno where you live, but becoming a physician assistant can be a pretty good gig: much less school, pretty good salaries, pretty defined hours, very little debt.
Personally, I worked at a series of toxic startups and needed two years away to not loath programming. I regret nothing about leaving tech the first time, and after returning, my biggest regret is waiting so long to start my own company. Closely followed by tolerating so many shitty bosses. It helped me to have friends that did things besides work; workaholics are very common in sfbay. Dunno if that helps, but good luck.