In principle every x86 operating system has this problem. The difference is in the expectations. If a laptop is certified for Windows 10 I expect it to run Windows 10 decently. If a laptop is Qubes OS certified, I expect it to run Qubes OS securely, with decent performance.
>>halomr+(OP)
What kind of issues have you seen with Qubes on vPro laptops?
Security is only meaningful within the context of a threat model. Qubes, like every operating system, has many possible configurations, for different threat models.