Every time I board a plane, I think what a crazy thing I am doing, but then I remember that I could be safe and snug in my house and still be in a plane crash.
To be fair, statistically, your living room is far more dangerous than the cabin of an airplane.
Background risk of death from non-natural causes are listed as 1.6 per day; many of those non-natural causes do not exist in an airplane cabin (e.g. you probably aren't going to be murdered because no one has anything more effective than a plastic spork, you probably aren't going to kill yourself, you probably won't be hit by a car). So it seems reasonable to say that being inside an airliner cabin is safer than being outside of one.
Also, this is probably confounded by many super-old or super-sick people not choosing to fly - if you are in an airliner, you are probably healthier than the average person.
Except for the occasional murder who has access to the flight controls.