> Ground observers reported the aircraft had been delayed for about two hours for work on the left hand engine (engine #1), the engine #1 separated during the takeoff run, the center engine emitted streaks of flames, the aircraft impacted a UPS warehouse and ploughed through other facilities before coming to rest in a large plume of fire and smoke.
So the tl'dr is: the leading very preliminary theory is that the MD-11's left engine fell off the wing just like https://en.wikipedia.org/wiki/American_Airlines_Flight_191 (a DC-10, the immediate predecessor of the MD-11) which was caused by maintenance errors weakening the pylon structure holding the engine.
1) improper maintenance—American Airlines had used a forklift shortcut to remove the engine and pylon together, rather than following McDonnell Douglas’s prescribed method
2) The detachment tore away part of the wing’s leading edge, rupturing hydraulic lines and severing electrical power to key systems, including the slat-position indicator and stall warning (stick shaker).
3) The pilots followed the standard engine-out procedure and reduced airspeed to V₂, which caused the aircraft to stall and roll uncontrollably left. This procedure was later found out to be incorrect.
Defective maintenance practices, inadequate oversight, vulnerabilities in DC-10 design, and unsafe training procedures combined to cause the crash, killing all 273 people on board and leading to sweeping reforms in airline maintenance and certification standards.
It's hard for me to tell if this suggests a step backwards in application of the reforms instigated after AA191 or that those reforms were never copied over to cargo aviation.
Furthermore (and I don't know if this is related to the cause of this crash), cargo jets tend to be older/refurbished passenger planes that have outlived their useful lives flying passengers.