I see some core team on this thread, so just wanted to say THANK YOU! Awesome job! Keep fighting for the users!
I'm totally the wrong person to offer recommendations on mobile, but so far it works very well for me, but then, I use almost no third party apps, and none of them are Play store only. My only complaint is the hardware (outside of their control).
I recommend putting proprietary Play Store apps grabbed with Aurora Store in the work profile with Shelter[5].
[1] https://obtainium.imranr.dev/
[3] https://f-droid.org/packages/com.aurora.store/
[4] https://f-droid.org/packages/de.marmaro.krt.ffupdater/
Also "private space" is now available with Android 15 and can provide the same separation within a single user profile.
Different use cases. User profiles are only active when you manually switch to them, while work profiles are active _alongside_ your main profile.
So for untrusted apps that you only use occasionally and on-demand (like the myriads of travel / shopping / random services apps), user profiles are great. For apps that you want to keep in the background, such as the proprietary messaging apps that all your friends use, a work profile is much nicer.
GrapheneOS supports having a Private Space in secondary users instead of only a single one in Owner. Supporting multiple Private Spaces per user is a planned feature at which point work profiles will be fully obsolete. The remaining use case for work profiles is to have both a Private Space and work profile in the Owner user.