Reliable energy? Possible, but difficult -- need plenty of batteries
Cooling? Very difficult. Where does the heat transfer to?
Latency? Highly variable.
Equipment upgrades and maintenance? Impossible.
Radiation shielding? Not free.
Decommissioning? Potentially dangerous!
Orbital maintenance? Gotta install engines on your datacenter and keep them fueled.
There's no upside, it's only downsides as far as I can tell.
If starcloud integrated with something like starlink, using the laser inter satellite links to distribute ground comms across a network of satellites, then the datacenter maintaining a direct link to a base station is probably a non-issue for most purposes.