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[return to "The risk of cancer fades past the age of 80"]
1. beguer+N6[view] [source] 2024-12-22 17:21:26
>>gpi+(OP)
This is against any established biological common sense I heard of: telomeres are known to be the mechanics of the DNA.

The enemy of these telomeres is age: damage occurs to them during cell division, hence the part of the DNA which watches after the DNA is no longer to fulfill its duty: and that is an open door to all types of cancer.

In other words, if nothing kills you at old age, cancer will do it.

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2. jacobl+T7[view] [source] 2024-12-22 17:32:22
>>beguer+N6
That's not entirely accurate. Telomeres shorten with age but cancers generally are triggered by mutations or defects much further in the DNA away from the telomeres.

So one hypothesis is that telomeres shrink with age which causes runaway growth (i.e. cancer) to burn up all it's telomeres early and start crunching through sequences responsible for building proteins essential to life, therefore causing some of the cancer cells to die out. Whether that hypothesis holds is a different matter but the referenced paper points towards various other mechanisms which are seemingly caused by cell age as well.

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