This alliance seems to be turning about two billion people and dozens of muslim-majority nations against America, driving them towards alliances with countries like China. American taxpayer money is being heavily invested in Israel. We're talking about a staggering $260 billion given to Israel, seemingly without direct benefits to the U.S. Ethically, the U.S. is on shaky ground. By consistently supporting Israel, even in cases involving civilian casualties, the U.S. appears to be undermining international law and the United Nations, often standing alone against global consensus. Looking at the U.S. presidency, it seems like candidates from both major parties have to win the favor of the Israeli lobby to secure their nomination. Take Obama, for example. Despite his apparent disdain for Netanyahu – remember the leaked conversation with Sarkozy where they called Netanyahu a liar? – he still seemed unable to counter the lobby's influence. This focus on Israel is a massive distraction from more pressing issues, like the rise of China.
And let's be clear – Israel's loyalty as a Western ally is questionable. It's kept friendly ties with the Kremlin, hasn't joined in sanctioning Russia, and has turned down requests to send defensive weapons to Ukraine. It seems Israel would not hesitate to shift its allegiance to China if it suited its national interests.
These lobbies then reach out to every lever of power and funds Israel friendly politicians (and even ones who are opposed to what Israel does - to neutralize their opposition - google "AIPAC AOC"). These offers of help (carrots) come with threats to primary the politician (sticks) if that politician goes against AIPAC's policies.
The only difference for Israel vs. other client states like Egypt, Japan, etc is the lack of vote required to keep funding going to Israel.