This alliance seems to be turning about two billion people and dozens of muslim-majority nations against America, driving them towards alliances with countries like China. American taxpayer money is being heavily invested in Israel. We're talking about a staggering $260 billion given to Israel, seemingly without direct benefits to the U.S. Ethically, the U.S. is on shaky ground. By consistently supporting Israel, even in cases involving civilian casualties, the U.S. appears to be undermining international law and the United Nations, often standing alone against global consensus. Looking at the U.S. presidency, it seems like candidates from both major parties have to win the favor of the Israeli lobby to secure their nomination. Take Obama, for example. Despite his apparent disdain for Netanyahu – remember the leaked conversation with Sarkozy where they called Netanyahu a liar? – he still seemed unable to counter the lobby's influence. This focus on Israel is a massive distraction from more pressing issues, like the rise of China.
And let's be clear – Israel's loyalty as a Western ally is questionable. It's kept friendly ties with the Kremlin, hasn't joined in sanctioning Russia, and has turned down requests to send defensive weapons to Ukraine. It seems Israel would not hesitate to shift its allegiance to China if it suited its national interests.
In US politics there are the Jews, the pro-Israel Lobby, and also part of the Evangelical Christian who strongly support Israel for religious reason (while sometime being a bit antisemitic). More generally American people strongly support Israel - even if some are criticizing decision made by Israel. Electorally all that is important.
Election aside, everybody have his own interest, but for many decade Israel had been a solid ally of the USA in the middle East - which is/was a key region. And the coming decades it is hard to see how it can change as both have interest to work with each other
Muslims that are unhappy with the current situation with Israel, were probably not huge fan of the USA and Israel in the first place... This did not prevent leaders of many Muslim countries to work closely with the USA and growingly more with Israel : national interest first. Of course the current event increase the pressure of the street over their leader to not work with Israel on the short term...
If USA were dropping big time a key ally in a key situation for this ally, this would send a very very bad signal to all allies. But we see that Biden is much more critical about Israel than USA used to be. While still being an ally.