The one thing you will need to do occasionally is experiment with different Wine distributions. This means you will need to right click on your game and select the distribution from a drop-down box. Exhausting, I know.
All games I want to play these days work under Linux without effort. Older titles work even better where under Windows you could run into compatibility issues not so under Linux because of the great effort put on backward compatibility by Wine.
Also, a bit susprising and unfortunate, the Windows version of a game that has native Linux support often runs better.
I run Manjaro Linux and have an Nvidia GPU for if it matters. My Steam games I run with Steam and for the games I bought on GOG I use Lutris.
I would really suggest people to check out how far it has come.