It’s usable and the security benefits are definitely important when working with multiple security domains (separate clients each with their own confidential data and third-party dependencies, where you don’t want one client’s malicious NPM dependency affecting the other).
However, there are cons. It’s only really usable in a stationary environment; it completely kills battery life and even basic tasks such as (non-HD) video display maxes out a single CPU core so it’s just not worth trying on a laptop. Hibernation doesn’t seem to be supported by default which becomes risky when combined with the extreme power usage.