What could one do to make it possible to have ME-less x86 in the future?
Joanna Rutkowska, Qubes founder, is the person who brought up intel ME as a problem in her paper Intel x86 considered harmful (https://blog.invisiblethings.org/papers/2015/x86_harmful.pdf).
If I can peek and poke around in your RAM as I please, no amount of cleverness is going to save you if my intentions are malicious.
(Don't worry, though, I have no such intentions, and I don't fiddle with other people's RAM as a matter of principle, unless they ask me to. ;-))