zlacker

To add something constructive:

I've used a novel nootropic which is an adenosine antagonist (KW-6356) for long-lasting energy without dopaminergic stimulation. Something I found and which is commonly reported by other users is mood-enhancing properties:

https://en.wikipedia.org/wiki/Sipagladenant

>>gavinr+(OP)
How do you know that's not frying some kind of receptor in your body? It seems there are no free lunches with antagonist drugs

>>candid+jl
The manufacturer doesn't make it clear why they axed it, but from my experience in med-tech I think this translates to "the FDA is going to balk at it"

https://www.kyowakirin.com/media_center/news_releases/2022/p...

>>candid+jl

  > How do you know that's not frying some kind of receptor in your body?

I don't. One of the things I enjoy about life is being able to experiment on my own body.