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1. MilkyW+(OP)[view] [source] 2025-12-06 00:50:28
"The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism"

More evidence for Chris Palmer's 'Metabolic Theory of Mental Disorders'

replies(1): >>Murome+J2
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2. Murome+J2[view] [source] 2025-12-06 01:18:19
>>MilkyW+(OP)
It kinda makes sense if you consider depression to be a mechanism to get into winter hibernation. It's just we can't hibernate and even if we could, somebody has to pay them bills.
replies(2): >>leobg+GD >>port11+n71
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3. leobg+GD[view] [source] [discussion] 2025-12-06 09:17:27
>>Murome+J2
That was the funniest social critique I’ve heard in a long time.
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4. port11+n71[view] [source] [discussion] 2025-12-06 14:42:30
>>Murome+J2
But are we built for hibernation? Or is the capacity for depression just a biological mistake for us?
replies(1): >>Murome+QX1
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5. Murome+QX1[view] [source] [discussion] 2025-12-06 22:01:15
>>port11+n71
We are not build for anything. It's a legacy codebase. Some stuff stopped working, but nobody removed the surrounding utility codes and the config entry to enable it.
replies(1): >>port11+QE2
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6. port11+QE2[view] [source] [discussion] 2025-12-07 06:29:03
>>Murome+QX1
Damned legacy code and technical debt always ruining everything.
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