https://www.hims.com/blog/daily-cialis-costs-benefits
https://investor.lilly.com/news-releases/news-release-detail...
It's superior to taking it on an as-needed basis because it has positive long term effects on your cardiovascular and penile tissue.
The startup company is Vivifi Medical[1] and they have clinical trials underway with ten men in a Central American country (El Salvador?). They claim that BPH reverses in a few months after their procedure. Their procedure uses a minimally invasive tool of their own invention to snip the vertical blood vessels that are backflowing from age and gravity, and splice them into some existing horizontal blood vessels. On their board of advisors is Dr. Billy Cohn[2], the wildly innovative heart surgeon who is famous for shopping for his medical device components at Home Depot. Dr. Cohn is on the team building the BiVACOR Total Artificial Heart. Vivifi presented their estimated timeline to FDA approval, with proposed general availability in 2028. My personal BPH will be at the head of the line for this procedure.
As far as a startup, their TAM is about 500 million men. I had the Urolift procedure for BPH three years ago, and it cost about $15K on the Medicare benefits statement, though Urolift's clips amounted to only a few thousand dollars. Similarly, Vivifi's charges for this procedure are only a few thousand dollars per procedure, but it holds the promise of being a final solution. Currently Urolift is much less disruptive than TURP, which needs a couple of days in the hospital and almost always leads to retrograde ejaculation (into the bladder).
it seemed to work for me, took it for few months, 10y+ ago. "Lasted" 8-9 years.. - until recently..
I ended up on this page which I no longer remember (something something prostatitis foundation maybe?), from which I remember two things.
The first was this turkish doctor, who against all advice was suggesting a "Brocolli juice therapy" as a prostatitis cure. Fast forward to 2025 and there's lots of studies supporting this. Anecdotally I tried this back then and it really helped the prostate pain I had at the time for months go away within a week.
The second, which is more relevant here, was this guy who had a very interesting hypothesis, that a lot of the prostate troubles are actually "musculoskeletal" in origin, and muscle imbalance / weakness of the iliopsoas muscles in particular. And that this imbalance affects venous return which "somehow" causes the condition. But he was just a lay person, and the "somehow" was unclear. So this completes that image perfectly. It's interesting that this article mentions the venous insufficiency link, and that veins rely on valves to direct flow, but doesn't mention the muscular link at all.
In any case, this person was saying that in his case, doing lots of iliopsoas stretching and exercises effectively 'fixed' his chronic prostatitis problems. So I've timidly started including a couple of iliopsoas stretching exercises before any workout I do. Anecdotally, I think it helps, but I can't know for sure. But thought I'd mention here in case someone shows interest or can make that link more solid.
PS. found the turkish doctor page (or at least a mirror of it): https://www.oocities.org/iastr/ebroc.htm
I wish I could find that comment about the iliopsoas ... but alas I think it's probably lost in the sands of time now.
UPDATE: Well what do you know. Found it: https://web.archive.org/web/20230203201759/https://prostatit...
(and https://web.archive.org/web/20230127101206/https://prostatit... more generally)
The life expectancy cited by Wikipedia for the paleolithic is around 39 additional years for those surviving to 15.
[1] https://en.m.wikipedia.org/wiki/Bandha_(yoga)#Mula_bandha
Are you planning to publish the longitudinal data, esp. of endpoints 2 and 3 (prostate size, urinary flow). It would greatly add to the public understanding of this procedure. Why didn't you go for PSA? It's easy to obtain altough one probably wouldn't expect significant changes in this short time frame.
Icelanders are a well-studied population when it comes to genetics. Frequency of some traits meaningfully changed among them in last 100 years.
Source: this book: https://www.amazon.de/dp/0198821263?ref_=pe_109184651_110380...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
I have no opinion of unlimitedhangout.com or the veracity of that article. But in response to "I just find it strange", I'm beginning to associate this sort of intensely intellectual inquiry into disparate topics with equally intense political positions.
I was first introduced to Urbit as if it was a purely technical, humorous and extremely nerdy lark. It was a joke thing my friend got me to sign up for, to own a slice of an imaginary universe (in a quantity called a "frigate" or whatever it was). When I learned years later about how serious the worldview behind it was, I was quite shocked.
Since then, and especially since the NYT outing of Scott Alexander in 2020, I've become more attuned to the pattern. These hyper-analytical blogs often come with a lot of political implications below the surface.
Again, I'm not taking sides here. If anything, the takeaway for me is that the world is very complicated. We have these rare polymath personalities who go deep into topics, have a strong voice on the internet, and they end up with all sorts of valid criticisms of the status quo. This in turn can align with extreme political views.
Quoting from the linked page:
> WHAT IS THE REASON THAT WE MUST CONSUME BOILED BROCCOLI?
> Fresh broccoli (unboiled) contains some enzymes that must be deactivated. The simple way to deactivate these enzymes is to boil the broccoli in water for 5 minutes. After boiling for 5 minutes, the enzymes will become inactive. If these enzymes aren't deactivated, the broccoli cannot successfully treat those suffering from BPH, prostatitis, or general urinary tract infections.
> Broccoli contains very important compounds. These compounds can only treat those who are suffering from BPH or prostatitis when these enzymes are deactivated. If this is not done, the enzymes which broccoli contains start a different metabolic reaction so that the efficiency is reduced.