zlacker

A New Mode of Cancer Treatment

submitted by atomro+(OP) on 2023-08-03 08:12:15 | 322 points 205 comments
[view article] [source] [go to bottom]

NOTE: showing posts with links only show all posts
◧◩◪
8. flobos+pm[view] [source] [discussion] 2023-08-03 11:18:35
>>irdc+Yf
Right! I forgot about good ol’ Lipinski: https://en.wikipedia.org/wiki/Lipinski%27s_rule_of_five
◧◩◪
24. jagged+lx[view] [source] [discussion] 2023-08-03 12:25:08
>>flobos+6v
One of the classics, his take on Chlorine Trifluoride (!!!!)

https://www.science.org/content/blog-post/sand-won-t-save-yo...

"It is also hypergolic with such things as cloth, wood, and test engineers, not to mention asbestos, sand, and water --- with which it reacts explosively."

- John D Clark, Ignition!: An Informal History of Liquid Rocket Propellants

◧◩◪◨
29. mallom+Ny[view] [source] [discussion] 2023-08-03 12:32:55
>>flobos+pm
Note that a number of well-known drugs violate Lipinski's rules. For instance, digoxin is absorbed by transporters and violates 2 rules. Atorvastatin is another famous example (again 2 rules violated). I believe that it is absorbed through Peyer's patches in the intestine.

https://www.pmf.ni.ac.rs/chemianaissensis/wp-content/uploads...

◧◩
31. ethbr0+cA[view] [source] [discussion] 2023-08-03 12:39:23
>>shireb+lu
> Well done science reporting without the hyperbole.

He's been doing it for 20 years.

https://www.statnews.com/2016/03/05/derek-lowe-chemist-blogg...

He also had an excellent series on SARS-CoV-2 vaccine candidates during the height of the COVID media insanity. It was one of the few places to get a balanced, informed take on different approaches. Specifically, discussing the uncertainty bounds around results.

Definitely a gifted science communicator. (No small skill, to distill but not pol/dilute!)

◧◩◪◨⬒
53. highwa+qU[view] [source] [discussion] 2023-08-03 14:19:09
>>midnit+VL
Not to be a bummer but by far the most likely outcome here is that we don’t currently have a room temperature super-conductor, we never pull a consequential amount of carbon out of the atmosphere, and we don’t get significantly workable sustainable fusion in a timeframe that makes a difference.

You’d need a bunch of jackpots to come up, in a row, immediately, at this point for technology to provide a way out of the current debacle.

To paraphrase Paul Lieberstein’s character on the Newsroom:

If we stop drilling globally right this second

AND

Everyone stops driving their car and starts biking everywhere

AND

We invest immediately in clean renewable energy

THEN

I still don’t see a way out of this.

edit: found it on YouTube https://m.youtube.com/watch?v=pNYp6oc37ds

◧◩◪◨
63. vander+031[view] [source] [discussion] 2023-08-03 14:57:39
>>jagged+lx
After which I recommend continuing with: https://www.science.org/content/blog-post/things-i-won-t-wor...
◧◩
75. realPt+Za1[view] [source] [discussion] 2023-08-03 15:36:33
>>shireb+lu
In case you’ve missed it. His blogposts at Science.org are available here: https://www.science.org/blogs/pipeline

I’ve had it bookmarked for a couple of years. Worth visiting twice or trice a year, or even more frequently.

◧◩◪
81. Burnin+4d1[view] [source] [discussion] 2023-08-03 15:46:53
>>nelox+0s
Temperatures can be lowered by pumping SO2 into the stratosphere. The effects are well understood.

The practical details should be figured out in a decade or so. The political side may be harder.

https://marginalrevolution.com/marginalrevolution/2023/07/su...

◧◩◪◨
91. darkcl+1f1[view] [source] [discussion] 2023-08-03 15:54:40
>>tejohn+kv
What ever came about from the CRU hack [1]?

I was walking my dog there most days when that happened, and to my knowledge they never caught the spooky hackers did they?

For now, just call me spooky Patsy.

Anyway, whilst more and more cars and buildings with air conditioning expel heat without a considerable lag, thus amplifying the thermal heat island effect [2], and the reduction of aerosols that were contributing to global dimming [3] making it possible to warm up the sea and land to new record highs since records began [4], have the climate scientists adjusted their models yet, or are they still in full on fatalism and alarmism mode? I feel like Roy Castle [5] still lives on.

[1] https://en.wikipedia.org/wiki/Climatic_Research_Unit_email_c...

[2] https://en.wikipedia.org/wiki/Urban_heat_island

[3] https://en.wikipedia.org/wiki/Global_dimming#Relationship_to...

[4] https://blog.metoffice.gov.uk/2023/06/16/sea-surface-tempera...

[5] https://en.wikipedia.org/wiki/Roy_Castle

◧◩◪
95. falcor+mh1[view] [source] [discussion] 2023-08-03 16:04:49
>>maximi+le1
I assumed the parent was referring to SpaceX's Starship [0].

[0] https://en.wikipedia.org/wiki/SpaceX_Starship

◧◩◪
96. highwa+wh1[view] [source] [discussion] 2023-08-03 16:05:21
>>gregsc+Qe1
2022. We’ve just forgotten because there’s been a lot going on.

https://en.wikipedia.org/wiki/National_Ignition_Facility

◧◩◪◨
107. George+mj1[view] [source] [discussion] 2023-08-03 16:13:04
>>glimsh+lb1
Hinton says we could very well be less than 5 years away: https://youtu.be/rGgGOccMEiY
159. flobos+k42[view] [source] 2023-08-03 19:43:19
>>atomro+(OP)
Martin Shkreli (yes, that Martin Shkreli) is currently running a virtual screen for additional PCNA inhibitors: https://twitter.com/wagieeacc/status/1687137621699436552
◧◩◪◨⬒⬓⬔
174. Burnin+qB2[view] [source] [discussion] 2023-08-03 22:17:55
>>Sketch+uw1
The distinction is important because at lower altitudes SO2 produces acid rain. But the stratosphere is far above the rain clouds.

NASA report on the Mount Pinatubo caused global cooling: https://earthobservatory.nasa.gov/images/1510/global-effects...

◧◩◪
175. jbotz+QF2[view] [source] [discussion] 2023-08-03 22:43:54
>>Vecr+Tv2
Usually, yes. But there do exist infectious cancers that spread between individuals. One is the face cancer that's been killing Tasmanian devils[0]... it started in one individual and spreads to others when they fight (biting each other). Apparently there's a similar (although rarer) cancers that's sexually transmitted between dogs.

[0] https://en.wikipedia.org/wiki/Devil_facial_tumour_disease

◧◩
181. adamre+de3[view] [source] [discussion] 2023-08-04 03:39:16
>>rowino+OA
That's the hope. I think Keytruda, aka Pembrolizumab, has also been a game-changer. It can run with other forms of treatment as well.

I hope we're entering a new epoch. The number of people I've met who've lost loved ones too early.

That dragon, cancer. https://en.wikipedia.org/wiki/That_Dragon,_Cancer

◧◩
183. adamre+Te3[view] [source] [discussion] 2023-08-04 03:47:32
>>flobos+k42
His history is not good.

>> Shkreli bought the exclusive rights to manufacture Daraprim, a drug that can treat a rare parasitic disease, in 2015 and hiked the price from $13.50 per pill to $750, to much controversy. The entrepreneur was ordered in January 2022 to return $64.6 million in profit made by the price hikes and creating what the Federal Trade Commission alleged was “a web of anti-competitive restrictions” to prevent rivals from making a cheaper generic version.

https://www.fastcompany.com/90932968/martin-shkreli-dr-gupta...

◧◩◪
184. flobos+1o3[view] [source] [discussion] 2023-08-04 05:32:04
>>soVery+KH2
Virtual screening[1] is a computational technique where you take an experimentally resolved structure of a protein (PCNA in this case) and sequentially dock a large amount of different compounds to see which ones of them bind favorably to the target protein. It is worth mentioning that virtual screening is a very early step in a drug discovery pipeline. These hits need to be characterized and validated experimentally to see if there is an actual effect.

I am not well-versed in intellectual property (so please correct me if I’m wrong), but in this case Shkreli is using a database of commercially available compounds (ZINC) and a hit present in the screen could be patented. He said he won’t do it, and, since this could be considered prior art, nobody else can do a claim.

[1]: https://en.wikipedia.org/wiki/Virtual_screening

[go to top]